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IsoDAR回旋加速器对放射性同位素生产的潜在影响:综述

What is the potential impact of the IsoDAR cyclotron on radioisotope production: a review.

作者信息

Waites Loyd H, Alonso Jose R, Barlow Roger, Conrad Janet M

机构信息

Physics Department, Massachusetts Institute of Technology, 26-540, MIT, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.

School of Computing and Engineering, The University of Huddersfield, Queensgate, Huddersfield, HD1 3DH, UK.

出版信息

EJNMMI Radiopharm Chem. 2020 Feb 3;5(1):6. doi: 10.1186/s41181-020-0090-3.

DOI:10.1186/s41181-020-0090-3
PMID:32016795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6997321/
Abstract

The IsoDAR collaboration is developing a high-current cyclotron for a neutrino search experiment. Designed to deliver 10 mA of 60 MeV protons, the current and power of this cyclotron far exceed those of existing accelerators, opening new possibilities for the production of radiopharmaceutical isotopes, producing very high-activity samples in very short times. The cyclotron can also be easily configured to deliver ions other than protons including 1 mA of alpha particles at 240 MeV: this flexibility gives a broad reach into new areas of isotope production. We explain how IsoDAR overcomes the beam limits of commercial cyclotrons, and how it could represent the next step in isotope production rates.

摘要

IsoDAR合作团队正在为一项中微子搜索实验研发一台高电流回旋加速器。该回旋加速器设计用于提供10毫安的60兆电子伏特质子,其电流和功率远远超过现有加速器,为放射性药物同位素的生产开辟了新的可能性,能够在极短时间内生产出高活度样本。该回旋加速器还可以轻松配置,以输送除质子以外的离子,包括240兆电子伏特下1毫安的阿尔法粒子:这种灵活性为同位素生产的新领域提供了广泛的应用范围。我们解释了IsoDAR如何克服商用回旋加速器的束流限制,以及它如何代表同位素生产率的下一步发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d9/6997321/e80f7e7a8322/41181_2020_90_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d9/6997321/2e98a5f8a4f8/41181_2020_90_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d9/6997321/1962eb5da873/41181_2020_90_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d9/6997321/d0820ef6c7c8/41181_2020_90_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d9/6997321/4b0ea9d6dec2/41181_2020_90_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d9/6997321/866010f6ec83/41181_2020_90_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d9/6997321/3ebcb4731b25/41181_2020_90_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d9/6997321/e80f7e7a8322/41181_2020_90_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d9/6997321/2e98a5f8a4f8/41181_2020_90_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d9/6997321/1962eb5da873/41181_2020_90_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d9/6997321/d0820ef6c7c8/41181_2020_90_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d9/6997321/4b0ea9d6dec2/41181_2020_90_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d9/6997321/866010f6ec83/41181_2020_90_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d9/6997321/3ebcb4731b25/41181_2020_90_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d9/6997321/e80f7e7a8322/41181_2020_90_Fig7_HTML.jpg

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本文引用的文献

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2
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Rev Sci Instrum. 2016 Feb;87(2):02B704. doi: 10.1063/1.4932395.
3
Proposal for an electron antineutrino disappearance search using high-rate 8Li production and decay.
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Phys Rev Lett. 2012 Oct 5;109(14):141802. doi: 10.1103/PhysRevLett.109.141802. Epub 2012 Oct 4.
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Proton-induced cross sections relevant to production of 225Ac and 223Ra in natural thorium targets below 200 MeV.低于200兆电子伏特时,质子在天然钍靶中诱发与产生225锕和223镭相关的截面。
Appl Radiat Isot. 2012 Nov;70(11):2602-7. doi: 10.1016/j.apradiso.2012.07.006. Epub 2012 Jul 11.
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Realizing the potential of the Actinium-225 radionuclide generator in targeted alpha particle therapy applications.认识到锕-225放射性核素发生器在靶向α粒子治疗应用中的潜力。
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