Pediatrics Department, Perlman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Pediatr Allergy Immunol. 2020 Feb;31 Suppl 24:25-27. doi: 10.1111/pai.13153.
Eosinophilic disorders of the gastrointestinal tract (EGID) are a group of diseases characterized by an eosinophilic inflammation limited to the GI tract. EoE is by far the most common EGID and is an atopic chronic/relapsing eosinophilic inflammation of the esophagus. It is now recognized as an increasingly common cause of esophageal dysfunction, fibrosis, stricture, and food impaction in children and adults. There are globally accepted guidelines for its treatment that are based on the use of proton pump inhibitors (PPI), corticosteroids, and diet. Many clinical trials have been published on the use of biologics in this disease. Non-EoE-EGID is a rare, more severe disease. No globally accepted guidelines exist for their treatment and diagnosis. Corticosteroids are at the moment the most effective treatment of those diseases.
胃肠道嗜酸性粒细胞疾病（EGID）是一组以局限于胃肠道的嗜酸性粒细胞炎症为特征的疾病。嗜酸性粒细胞性食管炎（EoE）是迄今为止最常见的 EGID，是一种特应性慢性/复发性嗜酸性粒细胞性食管炎。目前，它被认为是儿童和成人食管功能障碍、纤维化、狭窄和食物嵌塞的一个越来越常见的原因。目前有全球公认的治疗指南，其治疗方法基于质子泵抑制剂（PPI）、皮质类固醇和饮食的使用。在这种疾病中，已经发表了许多关于使用生物制剂的临床试验。非 EoE-EGID 是一种罕见的、更严重的疾病。目前尚无全球公认的治疗和诊断指南。皮质类固醇是目前治疗这些疾病最有效的方法。
