Ibrahim Mazin S, Ryan Sean, Seyler Thorsten, Arnold William V, Stoodley Paul, Haddad Fares
Instr Course Lect. 2020;69:229-242.
In the past, the diagnosis and treatment of periprosthetic joint infection (PJI) in joint arthroplasty has often been frustrating for orthopaedic surgeons. The application of certain diagnostic criteria and different treatment strategies can be better directed if these infections are placed in the context of microbial biofilms. An understanding of this biofilm mode of microbial infection can help to explain the phenomenon of culture-negative infection as well as provide an understanding of why certain treatment modalities often fail. Continued basic research into the role of biofilms in infection will likely provide improved strategies for the clinical diagnosis and treatment of PJI. This is a review of the current preclinical knowledge of biofilm in relation to PJI with an overview of current practices applied in the diagnosis, treatment, and prevention of biofilm formation in this setting.
过去，关节置换术中假体周围关节感染（PJI）的诊断和治疗常常让骨科医生感到沮丧。如果将这些感染置于微生物生物膜的背景下，某些诊断标准和不同治疗策略的应用可以更具针对性。了解这种微生物感染的生物膜模式有助于解释培养阴性感染的现象，并有助于理解为何某些治疗方式常常失败。对生物膜在感染中的作用持续进行基础研究，可能会为PJI的临床诊断和治疗提供改进策略。本文综述了目前与PJI相关的生物膜临床前知识，并概述了在这种情况下诊断、治疗和预防生物膜形成的当前实践。
