Mooney Jake A, Pridgen Eric M, Manasherob Robert, Suh Gina, Blackwell Helen E, Barron Annelise E, Bollyky Paul L, Goodman Stuart B, Amanatullah Derek F
Stanford University, School of Medicine, Stanford, California.
Department of Orthopaedic Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
J Orthop Res. 2018 Sep;36(9):2331-2339. doi: 10.1002/jor.24019. Epub 2018 May 24.
Periprosthetic joint infection (PJI) is a common complication after total joint arthroplasty leading to severe morbidity and mortality. With an aging population and increasing prevalence of total joint replacement procedures, the burden of PJI will be felt not only by individual patients, but in increased healthcare costs. Current treatment of PJI is inadequate resulting in incredibly high failure rates. This is believed to be largely mediated by the presence of bacterial biofilms. These polymicrobial bacterial colonies form within secreted extracellular matrices, adhering to the implant surface and local tissue. The biofilm architecture is believed to play a complex and critical role in a variety of bacterial processes including nutrient supplementation, metabolism, waste management, and antibiotic and immune resistance. The establishment of these biofilms relies heavily on the quorum sensing communication systems utilized by bacteria. Early stage research into disrupting bacterial communication by targeting quorum sensing show promise for future clinical applications. However, prevention of the biofilm formation via early forced induction of the biofilm forming process remains yet unexplored. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2331-2339, 2018.
人工关节周围感染（PJI）是全关节置换术后常见的并发症，可导致严重的发病和死亡。随着人口老龄化以及全关节置换手术的患病率不断上升，PJI的负担不仅会影响个体患者，还会导致医疗成本增加。目前对PJI的治疗并不充分，导致失败率极高。据信这在很大程度上是由细菌生物膜的存在介导的。这些多微生物细菌菌落形成于分泌的细胞外基质内，附着于植入物表面和局部组织。生物膜结构被认为在包括营养补充、代谢、废物管理以及抗生素和免疫抗性在内的各种细菌过程中发挥着复杂而关键的作用。这些生物膜的形成在很大程度上依赖于细菌利用的群体感应通讯系统。针对群体感应来破坏细菌通讯的早期研究显示出在未来临床应用中的前景。然而，通过早期强制诱导生物膜形成过程来预防生物膜形成仍未得到探索。© 2018年骨科研究协会。由威利期刊公司出版。《矫形外科学研究》36:2331 - 2339，2018年。
