Markiewcz Renata Anna, Markiewicz-Gospodarek Agnieszka, Kozioł Małgorzata, Szulecka Beata, Olajossy Marcin, Plech Tomasz
Uniwersytet Medyczny w Lublinie, Zakład Pielęgniarstwa Psychiatrycznego.
Uniwersytet Medyczny w Lublinie, Wydział Medycyny Weterynaryjnej, Katedra Anatomii i Histologii Zwierząt.
Psychiatr Pol. 2019 Dec 31;53(6):1275-1292. doi: 10.12740/PP/OnlineFirst/108491.
The aim of the study was to evaluate the level of cognitive and social functioning in two groups of schizophrenia patients using clinical tools, psychological tests, QEEG, and changes in the brain-derived neurotrophic factor (BDNF) activity in subjects' serum.
Randomly selected men diagnosed with schizophrenia were enrolled in the study and divided into two groups. Gr. 1 was formed by patients who did not undergo a structured rehabilitation program, while Gr. 2 was formed by patients undergoing standard rehabilitation, as provided in theprogramof the Psychiatric Rehabilitation Unit. Both groups underwent a comparative analysis of demographic parameters and based on: PANSS, AIS, GSES, and BCIS, psychological tests CTT-1, CTT-2, d2, QEEG, and changes in blood BDNF levels. To assess the effect of rehabilitation, the results obtained in both groups were compared after 12 weeks and their analysis was performed in accordance with assumptions for the experimental project. The study presents research hypotheses and pre-test and post-test comparisons of the groups, on the basis of selected research tools.
The data obtained in measurement 1 indicate that both groups did not differ significantly in terms of: age, education, place of residence, treatment at outpatient facilities, medicines taken, and suicide attempts. Differences concerned: marital status, children, number of hospitalizations, and employment status. Furthermore, no significant differences were found for the studied groups concerning: serum levels of the brain-derived neurotrophic factor, values obtained on the PANSS, AIS, and GSES, and alpha/theta, theta/beta and theta/SMR ratios. The analyses performed in measurement 2 indicate that structured rehabilitation influences reduce negative symptoms, cause an increase in BDNF levels, cause an improvement in cognitive and social functioning and positively influence the perception speed and accuracy.
The positive effect of structured rehabilitation influences allows to say that rehabilitation represents a necessary part of the comprehensive psychiatric treatment and should already be implemented during the first episode of the illness.
本研究旨在使用临床工具、心理测试、定量脑电图（QEEG）以及受试者血清中脑源性神经营养因子（BDNF）活性的变化，评估两组精神分裂症患者的认知和社会功能水平。
随机选取被诊断为精神分裂症的男性纳入研究并分为两组。第1组由未接受结构化康复计划的患者组成，而第2组由接受精神科康复单元计划中规定的标准康复治疗的患者组成。两组均对人口统计学参数进行了比较分析，并基于：阳性和阴性症状量表（PANSS）、攻击行为量表（AIS）、总体功能评估量表（GSES）和简明认知功能量表（BCIS），心理测试CTT - 1、CTT - 2、d2，定量脑电图（QEEG）以及血液中BDNF水平的变化。为评估康复效果，在12周后比较两组获得的结果，并根据实验项目的假设进行分析。该研究基于选定的研究工具提出了研究假设以及两组的测试前和测试后比较。
测量1中获得的数据表明，两组在以下方面无显著差异：年龄、教育程度、居住地点、门诊治疗情况、所服用药物以及自杀未遂情况。差异在于：婚姻状况、子女情况、住院次数和就业状况。此外，研究组在以下方面未发现显著差异：血清脑源性神经营养因子水平、在PANSS、AIS和GSES上获得的值，以及α/θ、θ/β和θ/SMR比率。测量2中进行的分析表明，结构化康复影响可减轻阴性症状，使BDNF水平升高，改善认知和社会功能，并对感知速度和准确性产生积极影响。
结构化康复影响的积极效果表明，康复是综合精神科治疗的必要组成部分，应在疾病的首次发作期间就予以实施。
