产前接触消毒副产物和氧化应激的血液及尿液生物标志物：一项重复测量分析。
Blood and urinary biomarkers of prenatal exposure to disinfection byproducts and oxidative stress: A repeated measurement analysis.
作者信息
Liu Chong, Wang Yi-Xin, Chen Ying-Jun, Sun Yang, Huang Li-Li, Cheng Ying-Hui, Liu Er-Nan, Lu Wen-Qing, Messerlian Carmen
机构信息
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
出版信息
Environ Int. 2020 Apr;137:105518. doi: 10.1016/j.envint.2020.105518. Epub 2020 Feb 1.
BACKGROUND
Toxicological studies have demonstrated that disinfection by-products (DBPs) can induce oxidative stress, a proposed mechanism that is relevant to adverse birth outcomes.
OBJECTIVE
To examine the associations of blood trihalomethanes (THMs) and urinary haloacetic acids (HAAs) with urinary biomarkers of oxidative stress among pregnant women.
METHODS
From 2015 to 2017, a total of 4150 blood and 4232 urine samples were collected from 1748 Chinese women during pregnancy. We determined concentrations of 4 blood THMs [chloroform (TCM), bromodichloromethane (BDCM), dibromochloromethane (DBCM), and bromoform (TBM)] and 2 urinary HAAs [dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA)]. The summary measures of exposure for brominated THMs (Br-THMs; a molar sum of BDCM, DBCM, and TBM) and total THMs (TTHMs; a molar sum of TCM and Br-THMs) were also calculated. Associations of categorical (i.e., tertiles) and continuous measures of DBPs with urinary concentrations of oxidative stress (OS) biomarkers, 8-hydroxy-2-deoxyguanosine (8-OHdG), 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA), and 8-iso-prostaglandin F (8-isoPGF), were assessed using linear mixed regression models.
RESULTS
After adjusting for relevant confounding factors, we observed positive dose-response relationships between blood Br-THM tertiles and urinary HNE-MA (P for trend < 0.001). We also found positive associations between tertiles of blood TCM and TTHMs and urinary 8-OHdG and HNE-MA (all P for trend < 0.05). Urinary HAAs were also positively associated with 8-OHdG, HNE-MA, and 8-isoPGF in a dose-response manner (all P for trend < 0.001). These associations were further confirmed when we modeled DBP exposures as continuous variables in linear mixed regression models, as well as in penalized regression splines based on generalized additive mixed models.
CONCLUSIONS
Exposure to DBPs during pregnancy may increase maternal OS status.
背景
毒理学研究表明，消毒副产物（DBPs）可诱导氧化应激，这是一种与不良出生结局相关的潜在机制。
目的
研究孕妇血液中三卤甲烷（THMs）和尿液中卤乙酸（HAAs）与氧化应激尿液生物标志物之间的关联。
方法
2015年至2017年期间，共收集了1748名中国孕妇的4150份血液样本和4232份尿液样本。我们测定了4种血液THMs[氯仿（TCM）、溴二氯甲烷（BDCM）、二溴氯甲烷（DBCM）和溴仿（TBM）]以及2种尿液HAAs[二氯乙酸（DCAA）和三氯乙酸（TCAA）]的浓度。还计算了溴化THMs（Br-THMs；BDCM、DBCM和TBM的摩尔总和）和总THMs（TTHMs；TCM和Br-THMs的摩尔总和）的暴露汇总指标。使用线性混合回归模型评估DBPs的分类（即三分位数）和连续测量值与氧化应激（OS）生物标志物、8-羟基-2-脱氧鸟苷（8-OHdG）、4-羟基-2-壬烯醛-巯基尿酸（HNE-MA）和8-异前列腺素F（8-isoPGF）尿液浓度之间的关联。
结果
在调整相关混杂因素后，我们观察到血液Br-THM三分位数与尿液HNE-MA之间存在正剂量反应关系（趋势P<0.001）。我们还发现血液TCM和TTHMs的三分位数与尿液8-OHdG和HNE-MA之间存在正相关（所有趋势P<0.05）。尿液HAAs也与8-OHdG、HNE-MA和8-isoPGF呈剂量反应正相关（所有趋势P<0.001）。当我们在线性混合回归模型中将DBP暴露建模为连续变量时，以及在基于广义相加混合模型的惩罚回归样条中，这些关联得到了进一步证实。
结论
孕期接触DBPs可能会增加孕妇的OS状态。
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