Department of Clinical Laboratory, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Department of Clinical Laboratory, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China,
Ophthalmic Res. 2020;63(4):413-422. doi: 10.1159/000504450. Epub 2020 Feb 4.
We aimed to evaluate whether the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune inflammation index (SII) were associated with primary open-angle glaucoma (POAG).
This retrospective case-control study included 240 patients with POAG and 300 age- and sex-matched control subjects. Complete ophthalmological examination and blood count measurements were performed for all subjects.
The values of NLR, PLR, and SII in the POAG group were significantly increased compared with the control group (p < 0.001; p = 0.012; p < 0.001). However, the LMR value was lower in the POAG patients than in the control group (p < 0.001). When we divided the subjects into different age and gender subgroups, the NLR and SII values in the POAG patients were always higher than those in the control group. In the comparison of laboratory parameters in POAG subjects stratified according to severity, we also found that NLR and SII increased with the severity. The receiver operating characteristic (ROC) analysis revealed that the areas under the ROC curve of NLR, PLR, LMR, and SII to predict patients with POAG were found to be 0.627, 0.569, 0.382, and 0.986, respectively. The best cutoff point of NLR was 1.998 with a sensitivity of 59.8% and a specificity of 63.0%, and the SII was 947.365 with a sensitivity of 95.4% and a specificity of 95.7%. Multivariable logistic regression analysis showed that NLR was positively associated with mean deviation; moreover, NLR and SII were independent indicators correlated with POAG (OR 1.502; 95% CI 1.227-1.839; p < 0.001; OR 1.02; 95% CI 1.009-1.021; p < 0.001).
We speculated that elevated NLR and SII might serve as readily available inflammatory predictors in POAG patients.
本研究旨在评估中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、淋巴细胞与单核细胞比值（LMR）和全身免疫炎症指数（SII）与原发性开角型青光眼（POAG）之间的关系。
本回顾性病例对照研究纳入了 240 名 POAG 患者和 300 名年龄和性别匹配的对照组。所有受试者均进行了全面的眼科检查和血细胞计数测量。
POAG 组的 NLR、PLR 和 SII 值明显高于对照组（p < 0.001；p = 0.012；p < 0.001）。然而，POAG 患者的 LMR 值低于对照组（p < 0.001）。当我们将受试者分为不同年龄和性别亚组时，POAG 患者的 NLR 和 SII 值始终高于对照组。在根据严重程度对 POAG 患者进行分层的实验室参数比较中，我们还发现 NLR 和 SII 随着严重程度的增加而增加。受试者工作特征（ROC）分析显示，NLR、PLR、LMR 和 SII 预测 POAG 患者的 ROC 曲线下面积分别为 0.627、0.569、0.382 和 0.986。NLR 的最佳截断值为 1.998，灵敏度为 59.8%，特异性为 63.0%，SII 的最佳截断值为 947.365，灵敏度为 95.4%，特异性为 95.7%。多变量逻辑回归分析表明，NLR 与平均偏差呈正相关；此外，NLR 和 SII 是与 POAG 相关的独立指标（OR 1.502；95%CI 1.227-1.839；p < 0.001；OR 1.02；95%CI 1.009-1.021；p < 0.001）。
我们推测升高的 NLR 和 SII 可能是 POAG 患者易于获得的炎症预测指标。
