评估中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值和全身免疫炎症指数作为新生儿败血症的诊断标志物。
Assessment of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and systemic immune-inflammatory index, as diagnostic markers for neonatal sepsis.
机构信息
Department of Pediatrics, The First People's Hospital of Linping District, Hangzhou, China.
Department of Emergency, The Second Affiliated Hospital Of Zhejiang University, Hangzhou, China.
出版信息
J Int Med Res. 2024 Aug;52(8):3000605241270696. doi: 10.1177/03000605241270696.
OBJECTIVE
To assess the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and systemic immune-inflammatory index (SII), as diagnostic markers for neonatal sepsis.
METHODS
This retrospective study involve neonates with sepsis and healthy neonates as controls. NLR, PLR, and SII were compared between groups.
RESULT
In total, 60 neonates with sepsis and 60 healthy controls were involved in the study. Compared with controls, the sepsis group had higher values for NLR, PLR and SII. Logistic regression analysis suggested that the NLR, PLR and SII were independent risk factors for neonatal sepsis. In addition, receiver operating characteristic (ROC) curve analysis indicated that the NLR, PLR and SII were reliable predictors of neonatal sepsis and SII had the best predictive value.
CONCLUSIONS
NLR, PLR and SII appear to be useful indicators for predicting neonatal sepsis.
目的
评估中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）和全身免疫炎症指数（SII）作为新生儿败血症的诊断标志物。
方法
本回顾性研究纳入了败血症新生儿和健康新生儿作为对照。比较了各组之间的 NLR、PLR 和 SII。
结果
本研究共纳入 60 例败血症新生儿和 60 例健康对照。与对照组相比，败血症组的 NLR、PLR 和 SII 值更高。Logistic 回归分析表明，NLR、PLR 和 SII 是新生儿败血症的独立危险因素。此外，受试者工作特征（ROC）曲线分析表明，NLR、PLR 和 SII 是新生儿败血症的可靠预测指标，而 SII 具有最佳的预测价值。
结论
NLR、PLR 和 SII 似乎是预测新生儿败血症的有用指标。
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