Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, No.100 Hong Kong Road, 430015, Wuhan, China.
Pediatr Res. 2020 Oct;88(4):668-675. doi: 10.1038/s41390-020-0794-9. Epub 2020 Feb 4.
Maternal hypertensive disorders of pregnancy (HDP) are the major causes of maternal mortality. However, the association between HDP and offspring's neurodevelopment remains unclear.
Participants were 4031 singleton live births from a prospective cohort study in Wuhan, China, during October 2013 to October 2014. Neurodevelopment of infant was evaluated by using Chinese version of Gesell Developmental Schedules at 0.5 year of age. Maternal HDP and potential confounders were ascertained by healthcare records at baseline.
Generalized linear model analysis indicated that maternal chronic hypertension were significantly associated with development quotient on fine motor (β = -3.32, 95% CI: -6.33 to -0.31), adaptability (β = -2.87, 95% CI: -5.31 to -0.43), language (β = -1.23, 95% CI: -2.12 to -0.34) and social behavior (β = -2.53, 95% CI: -4.69 to -0.37), and gestational hypertension was significantly associated with development quotient on social behavior (β = -1.42, 95% CI: -2.03 to -0.81), even after adjustment of major confounders. Multivariable logistic regression analysis showed that maternal chronic hypertension also increased the risk of diagnosis of "neurodevelopmental delay" on fine motor (OR = 1.85, 95% CI: 1.19-2.89), adaptability (OR = 2.32, 95% CI: 1.42-3.78), language (OR = 2.86, 95% CI: 1.74-4.70), and social behavior (OR = 2.13, 95% CI: 1.73-2.59).
This study suggests that exposure to HDP is associated with an increased risk of neurodevelopment impairment in the offspring at the age of 0.5 year.
孕妇高血压疾病（HDP）是孕产妇死亡的主要原因。然而，HDP 与后代神经发育之间的关系尚不清楚。
参与者为 2013 年 10 月至 2014 年 10 月期间来自中国武汉一项前瞻性队列研究中的 4031 例单胎活产儿。在 0.5 岁时使用中国版盖塞尔发育量表评估婴儿的神经发育情况。在基线时通过医疗记录确定 HDP 母亲和潜在混杂因素。
广义线性模型分析表明，慢性高血压母亲与精细运动发育商（β=-3.32，95%CI：-6.33 至-0.31）、适应性（β=-2.87，95%CI：-5.31 至-0.43）、语言（β=-1.23，95%CI：-2.12 至-0.34）和社会行为（β=-2.53，95%CI：-4.69 至-0.37）显著相关，妊娠期高血压与社会行为的发育商（β=-1.42，95%CI：-2.03 至-0.81）显著相关，即使在调整了主要混杂因素后也是如此。多变量逻辑回归分析表明，慢性高血压母亲也增加了精细运动（OR=1.85，95%CI：1.19-2.89）、适应性（OR=2.32，95%CI：1.42-3.78）、语言（OR=2.86，95%CI：1.74-4.70）和社会行为（OR=2.13，95%CI：1.73-2.59）发育障碍的诊断风险。
本研究表明，HDP 暴露与 0.5 岁时后代神经发育受损的风险增加有关。
