Department of Biochemistry and Molecular Biology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, PR China.
Department of Biochemistry and Molecular Biology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, PR China.
Sci Total Environ. 2020 Apr 20;714:136811. doi: 10.1016/j.scitotenv.2020.136811. Epub 2020 Jan 21.
To test the relationship not yet explored before among earthquake and related environmental factors, low-density lipoprotein receptor (LDLR) and posttraumatic stress disorder (PTSD), the genetic variation of LDLR rs5925 was selected and PTSD was examined by PTSD Checklist-Civilian Version (PCLC) in adolescents with different genotypes of LDLR rs5925 longitudinally at 6, 12 and 18 months after the 2008 Wenchuan earthquake. The C allele carriers were observed to have higher PTSD prevalence than the TT homozygotes in the male subjects, and higher PTSD prevalence and PCL-C scores in the female subjects only at 6 months. When compared to that at 12 months, decreased PTSD prevalence was observed at 18 months only in the female C allele carriers, but not in the female TT homozygotes or the male subjects. The potential risk factors of PTSD and predictors of PCL-C scores were different during the follow-up. LDLR rs5925 was one of the predictors for PCL-C scores at 6 and 12 months, and one of the potential factors for PTSD prevalence at 6 months. These results suggest that interactions may occur between earthquakes and other related environmental factors, which could affect the relationship of LDLR rs5925 with PTSD and be considered for individualized treatment.
为了检验地震与相关环境因素、低密度脂蛋白受体（LDLR）和创伤后应激障碍（PTSD）之间以前尚未探讨过的关系，选择 LDLR rs5925 的遗传变异，并用 PTSD Checklist-Civilian 版（PCLC）在 2008 年汶川地震后 6、12 和 18 个月时，对不同 LDLR rs5925 基因型的青少年进行纵向检查。在男性受试者中，C 等位基因携带者的 PTSD 患病率高于 TT 纯合子，而在女性受试者中，仅在 6 个月时，C 等位基因携带者的 PTSD 患病率和 PCLC 评分更高。与 12 个月相比，仅在女性 C 等位基因携带者中，18 个月时 PTSD 患病率降低，但在女性 TT 纯合子或男性受试者中未观察到这种情况。在随访期间，PTSD 的潜在危险因素和 PCLC 评分的预测因素不同。LDLR rs5925 是 6 个月和 12 个月时 PCLC 评分的预测因素之一，也是 6 个月时 PTSD 患病率的潜在因素之一。这些结果表明，地震与其他相关环境因素之间可能存在相互作用，这可能会影响 LDLR rs5925 与 PTSD 的关系，并考虑进行个体化治疗。
