乙型肝炎病毒 RNA 合成中的宿主转录因子。

Host Transcription Factors in Hepatitis B Virus RNA Synthesis.

机构信息

Alberta RNA Research and Training Institute, Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Dr. W., Lethbridge, AB T1K 3M4, Canada.

Department of Microbiology, Immunology and Infectious Diseases, Cumming, School of Medicine, University of Calgary, 2500 University Dr. N.W., Calgary, AB T2N 1N4, Canada.

出版信息

Viruses. 2020 Jan 30;12(2):160. doi: 10.3390/v12020160.

DOI:10.3390/v12020160

PMID:32019103

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7077322/

Abstract

The hepatitis B virus (HBV) chronically infects over 250 million people worldwide and is one of the leading causes of liver cancer and hepatocellular carcinoma. HBV persistence is due in part to the highly stable HBV minichromosome or HBV covalently closed circular DNA (cccDNA) that resides in the nucleus. As HBV replication requires the help of host transcription factors to replicate, focusing on host protein-HBV genome interactions may reveal insights into new drug targets against cccDNA. The structural details on such complexes, however, remain poorly defined. In this review, the current literature regarding host transcription factors' interactions with HBV cccDNA is discussed.

摘要

乙型肝炎病毒（HBV）在全球范围内慢性感染超过 2.5 亿人，是导致肝癌和肝细胞癌的主要原因之一。HBV 的持续存在部分归因于高度稳定的 HBV 微染色体或 HBV 共价闭合环状 DNA（cccDNA），它存在于细胞核中。由于 HBV 复制需要宿主转录因子的帮助才能进行，因此关注宿主蛋白与 HBV 基因组的相互作用可能会揭示针对 cccDNA 的新药物靶点的见解。然而，这些复合物的结构细节仍未得到充分定义。在这篇综述中，讨论了当前关于宿主转录因子与 HBV cccDNA 相互作用的文献。