系统性红斑狼疮患者免疫细胞中的 DNA 甲基化改变。
DNA methylation changes on immune cells in Systemic Lupus Erythematosus.
机构信息
School of Graduate Studies and School of Medicine, CES University, Medellin, Colombia.
School of Nursery, CES University, Medellin, Colombia.
出版信息
Autoimmunity. 2020 May;53(3):114-121. doi: 10.1080/08916934.2020.1722108. Epub 2020 Feb 4.
Abstract
DNA methylation as a process that regulates gene expression is crucial in immune cells biology. Global and gene specific methylation changes have been described in autoimmunity, especially in Systemic Lupus Erythematosus. These changes not only contribute to the understanding of the disease, but also some have been proposed as diagnostic or disease activity biomarkers. The present review compiles the most recent discoveries on this field on each type of immune cells, including specific changes in signalling pathways, genes of interest and its possible applications on diagnosis or treatment.
摘要
DNA 甲基化作为一种调节基因表达的过程，在免疫细胞生物学中至关重要。在自身免疫性疾病中，特别是在系统性红斑狼疮中，已经描述了全球和基因特异性甲基化变化。这些变化不仅有助于理解疾病，而且一些已经被提议作为诊断或疾病活动的生物标志物。本综述汇集了该领域在每种免疫细胞类型中的最新发现，包括信号通路、感兴趣的基因的特异性变化及其在诊断或治疗中的可能应用。
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