TET 蛋白与 DNA 甲基化在细胞中的争夺战
The Battle between TET Proteins and DNA Methylation for the Right Cell.
机构信息
CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 511436, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 511436, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China.
出版信息
Trends Cell Biol. 2018 Dec;28(12):973-975. doi: 10.1016/j.tcb.2018.10.002. Epub 2018 Nov 3.
DNA methylation is an important epigenetic barrier during somatic cell reprogramming. Yet, how genome-wide methylation is reprogrammed remains largely unknown. Sardina et al. (Cell Stem Cell 2018:https://doi.org/10.1016/j.stem.2018.08.016) address this question by mapping the DNA methylomes of cells undergoing reprogramming and show that TET proteins and transcription factors cooperate to orchestrate demethylation critical to reprogramming.
DNA 甲基化是体细胞重编程过程中的一个重要表观遗传屏障。然而，全基因组甲基化是如何被重新编程的，在很大程度上仍然未知。Sardina 等人（Cell Stem Cell 2018：https://doi.org/10.1016/j.stem.2018.08.016）通过绘制重编程细胞的 DNA 甲基组图谱，解决了这个问题，他们表明 TET 蛋白和转录因子合作，共同协调重编程过程中至关重要的去甲基化作用。
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