Arora Navneet, Wasti Kushal P, Babbar Navida, Saroch Atul, Pannu Ashok K, Sharma Navneet
Senior Resident, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
MD Resident, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Trop Doct. 2020 Apr;50(2):165-166. doi: 10.1177/0049475520903651. Epub 2020 Feb 4.
Related neurological adverse effects to metronidazole are rarely encountered in clinical practice despite its wide use as an antibacterial or antiparasitic agent. The neurotoxicity is not dose-dependent and is fully reversible with discontinuation of the drug. We describe a young man who was receiving metronidazole for an amoebic liver abscess and developed encephalopathy and seizures. Brain magnetic resonance imaging showed characteristic bilateral symmetrical cerebellar dentate hyperintensities.
尽管甲硝唑作为抗菌或抗寄生虫药物被广泛使用，但在临床实践中很少遇到与之相关的神经不良反应。神经毒性与剂量无关，停药后可完全逆转。我们描述了一名年轻男性，他因阿米巴肝脓肿接受甲硝唑治疗，随后出现脑病和癫痫发作。脑部磁共振成像显示双侧小脑齿状核有特征性的对称性高信号。
