Department of Medicine, Emory University, Emory Critical Care Center, Atlanta, GA, USA.
Emory Johns Creek Hospital, 6325 Hospital Parkway, Johns Creek, GA, 30097, USA.
Crit Care. 2020 Feb 4;24(1):36. doi: 10.1186/s13054-020-2743-8.
Vasoplegic syndrome is a common occurrence following cardiothoracic surgery and is characterized as a high-output shock state with poor systemic vascular resistance. The pathophysiology is complex and includes dysregulation of vasodilatory and vasoconstrictive properties of smooth vascular muscle cells. Specific bypass machine and patient factors play key roles in occurrence. Research into treatment of this syndrome is limited and extrapolated primarily from that pertaining to septic shock, but is evolving with the expanded use of catecholamine-sparing agents. Recent reports demonstrate potential benefit in novel treatment options, but large clinical trials are needed to confirm.
血管麻痹综合征是心胸外科手术后的常见并发症，其特征为高心输出量性休克状态，伴有全身血管阻力降低。其病理生理学机制复杂，包括血管平滑肌细胞舒缩功能失调。特定的体外循环机器和患者因素在其发生中起着关键作用。针对该综合征的治疗研究有限，主要从脓毒性休克的相关研究中推断而来，但随着儿茶酚胺节约剂的广泛应用，治疗方法也在不断发展。最近的报告显示，新型治疗选择可能具有潜在益处，但仍需要大型临床试验来证实。
