Moëll C, Garwicz S, Marky I, Mellander L, Karlberg J
Department of Paediatrics, University Hospital, Lund, Sweden.
Acta Paediatr Scand. 1988 Sep;77(5):688-92. doi: 10.1111/j.1651-2227.1988.tb10731.x.
Growth and weight gain were studied longitudinally over a period of four years in thirty-nine children treated for acute lymphoblastic leukemia. The children were divided into two groups according to treatment. Twenty-eight children were given prophylactic cranial irradiation and eleven children were treated without such irradiation. The duration of cytostatic treatment was three years in all cases. Average growth during the first two years was similar in the two groups, and the standard deviation scores (SDS) were below average. The rate of growth (in height) during the fourth year was significantly higher among those children who had not received cranial irradiation (p less than 0.01). After four years the average attained height had declined 0.5 SD for children treated with cranial irradiation and 0.2 SD for children without such treatment. Weight velocity was significantly greater than the expected mean in the non-irradiated group during the first year and in the irradiated group during the fourth year of the study. Attained weight after four years had increased 0.4 SD more among those children who had not received irradiation. The results suggest that prophylactic cranial irradiation is responsible for the greater part of the prepubertal growth inhibition in these children.
对39名接受急性淋巴细胞白血病治疗的儿童进行了为期四年的纵向生长和体重增加情况研究。根据治疗方式将儿童分为两组。28名儿童接受了预防性颅脑照射，11名儿童未接受此类照射。所有病例的细胞抑制治疗持续时间均为三年。两组在前两年的平均生长情况相似，标准差评分（SDS）低于平均水平。在未接受颅脑照射的儿童中，第四年的生长速率（身高方面）显著更高（p小于0.01）。四年后，接受颅脑照射的儿童平均身高下降了0.5个标准差，未接受此类治疗的儿童平均身高下降了0.2个标准差。在研究的第一年，未接受照射组的体重增长速度显著高于预期均值，在第四年，接受照射组的体重增长速度显著高于预期均值。四年后，未接受照射的儿童的体重增加比接受照射的儿童多0.4个标准差。结果表明，预防性颅脑照射是这些儿童青春期前生长抑制的主要原因。
