与肛门直肠畸形发展相关的危险因素。一项病例对照研究。
Risk factors associated with anorectal malformations development. A case-control study.
机构信息
Saudi Board of Preventive Medicine, Taibah University, Al Madinah Al Munnawarah, Kingdom of Saudi Arabia. E-mail.
出版信息
Saudi Med J. 2020 Feb;41(2):157-162. doi: 10.15537/smj.2020.2.24882.
To determine the risk factors for the development of anorectal malformations (ARM). Methods: This case-control study was conducted in the Maternity and Children Hospital (MCH), Al Madinah Al Munnawarah, Saudi Arabia. The sample was taken from the ARM cases admitted at MCH between January 2013 and December 2017. The controls were selected from well-baby clinics in primary health care centers. Parents of the cases and the controls were interviewed based on a questionnaire. Descriptive, univariate, and multivariate logistic regression were used in the analysis. Results: The study included 48 cases and 96 controls with 31 (64.6%) cases of isolated ARM and 17 (35.4%) cases of associated ARM. Among the ARM cases, 27 (56.3%) were males and 21 (43.8%) were females. In multivariate analysis, we found consanguinity to be associated with an increased risk of developing ARM with odds ratio (OR): 2.43, 95% CI: 1.12-5, and p=0.025, in addition to maternal obesity, with OR: 4.36, 95% CI: 1.2-15.8, and p=0.025. Conclusion: Consanguinity and maternal obesity (body mass index more than 30) were found to be risk factors for ARM development.
目的
确定肛门直肠畸形（ARM）发生的危险因素。方法：这是一项在沙特麦地那的母婴医院（MCH）进行的病例对照研究。样本取自 2013 年 1 月至 2017 年 12 月期间在 MCH 住院的 ARM 病例。对照组则选自初级保健中心的婴儿诊所。根据问卷对病例和对照组的父母进行访谈。采用描述性、单变量和多变量逻辑回归进行分析。结果：研究共纳入 48 例病例和 96 例对照，其中 31 例（64.6%）为单纯性 ARM，17 例（35.4%）为合并性 ARM。在 ARM 病例中，男性 27 例（56.3%），女性 21 例（43.8%）。多变量分析发现，近亲结婚与 ARM 的发生风险增加相关，比值比（OR）为 2.43，95%可信区间（CI）为 1.12-5，p=0.025，此外，母亲肥胖（体重指数超过 30）与 OR：4.36，95%CI：1.2-15.8，p=0.025。结论：近亲结婚和母亲肥胖（体重指数超过 30）被发现是 ARM 发展的危险因素。
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