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开始静脉-静脉体外膜肺氧合后尽早行气管切开术与体外膜肺氧合支持时间缩短有关。

Early tracheostomy after initiation of venovenous extracorporeal membrane oxygenation is associated with decreased duration of extracorporeal membrane oxygenation support.

机构信息

Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.

Lung Rescue Unit, R Adams Cowley Shock Trauma Center, Baltimore, MD, USA.

出版信息

Perfusion. 2020 Sep;35(6):509-514. doi: 10.1177/0267659119898327. Epub 2020 Feb 5.

Abstract

Timing of tracheostomy placement for patients with respiratory failure requiring venovenous extracorporeal membrane oxygenation support is variable and continues to depend on surgeon preference. We retrospectively reviewed all consecutive adult patients supported with peripheral venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome at a single institution with the hypothesis that early tracheostomy (within 7 days of extracorporeal membrane oxygenation initiation) decreases the duration of extracorporeal membrane oxygenation support. The primary endpoint was duration of extracorporeal membrane oxygenation support. Secondary endpoints included mortality, overall and intensive care unit length of stay, duration of mechanical ventilation, and time from extracorporeal membrane oxygenation initiation to liberation from ventilator, intensive care unit discharge, and hospital discharge. Overall and extracorporeal membrane oxygenation-associated hospital costs were compared. A total of 50 patients were identified for inclusion (early n = 21; late n = 29). Baseline characteristics including indices of disease severity were similar between groups. Duration of extracorporeal membrane oxygenation support was significantly shorter in the early tracheostomy group (12 vs. 21 days; p = 0.005). Median extracorporeal membrane oxygenation-related costs were significantly decreased in the early tracheostomy group ($3,624 vs. $5,603, p = 0.03). Early tracheostomy placement is associated with decreased time on extracorporeal membrane oxygenation support and reduced extracorporeal membrane oxygenation-related costs in this cohort. Validation in a prospective cohort or a clinical trial is indicated.

摘要

对于需要静脉-静脉体外膜肺氧合支持的呼吸衰竭患者,气管切开术的时机是可变的,仍然取决于外科医生的偏好。我们回顾性分析了在一家机构接受外周静脉-静脉体外膜肺氧合治疗急性呼吸窘迫综合征的所有连续成年患者,假设早期气管切开术(在体外膜肺氧合开始后 7 天内)可缩短体外膜肺氧合支持时间。主要终点是体外膜肺氧合支持时间。次要终点包括死亡率、总住院时间和重症监护病房住院时间、机械通气时间以及从体外膜肺氧合开始到呼吸机撤离、重症监护病房出院和出院的时间。比较了总费用和体外膜肺氧合相关的医院费用。共确定了 50 例患者纳入研究(早期 n=21;晚期 n=29)。两组的基线特征,包括疾病严重程度指数,均相似。早期气管切开组体外膜肺氧合支持时间明显缩短(12 天与 21 天;p=0.005)。早期气管切开组体外膜肺氧合相关费用中位数显著降低(3624 美元与 5603 美元,p=0.03)。在该队列中,早期气管切开术与体外膜肺氧合支持时间缩短和体外膜肺氧合相关费用降低相关。需要在前瞻性队列或临床试验中进行验证。

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