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乳腺癌放疗期间淋巴细胞计数最低点时淋巴细胞相关血液参数的预测价值

Predictive Value of Lymphocyte-Related Blood Parameters at the Time Point of Lymphocyte Nadir During Radiotherapy in Breast Cancer.

作者信息

Liu Jiannan, Ma Feiyan, Sun Bing, Cong Yang, Xuan Liang, Wang Qian, Wu Shikai

机构信息

Academy of Military Medical Sciences, Beijing 100039, People's Republic of China.

Department of Radiation Oncology, The Fifth Medical Center of Chinese PLA General Hospital (Former 307th Hospital of the PLA), Beijing 100071, People's Republic of China.

出版信息

Onco Targets Ther. 2020 Jan 8;13:151-161. doi: 10.2147/OTT.S233244. eCollection 2020.

DOI:10.2147/OTT.S233244
PMID:32021263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6955599/
Abstract

PURPOSE

Various reports found a relationship between lymphocyte-related blood parameters (LRBP), including absolute lymphocyte counts (ALC), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) and prognosis of breast cancer. Most of the studies focused on LRBP pre-treatment. Seldom have studies focused on LRBP during radiotherapy. We intended to perform a retrospective cohort study on the prognostic value of LRBP at the time point of lowest ALC during radiotherapy for breast cancer.

PATIENTS AND METHODS

A total of 158 female patients were included in radiotherapy group because of the strict limitation standards of complete routine blood test results at pre-treatment and pre-operation, and at least once a week during radiotherapy. Besides 221 patients, including the 158 patients of radiotherapy group, were adopted in pre-treatment group and pre-operation group.

RESULTS

ALC and PLR at the time point of lowest ALC during radiotherapy are prognostic predictors of breast cancer, and lower ALC and higher PLR are independent significant predictors of poor DFS. Besides, lower ALC, higher NLR and higher PLR at both pre-treatment and pre-operation were found to be independent variables for predicting poor DFS.

CONCLUSION

LRBP at pre-treatment, pre-operation, and during radiotherapy may serve as predictors of outcomes of breast cancer.

摘要

目的

多项报告发现淋巴细胞相关血液参数（LRBP），包括绝对淋巴细胞计数（ALC）、中性粒细胞与淋巴细胞比值（NLR）以及血小板与淋巴细胞比值（PLR）与乳腺癌预后之间存在关联。大多数研究聚焦于治疗前的LRBP。很少有研究关注放疗期间的LRBP。我们旨在对乳腺癌放疗期间最低ALC时间点的LRBP预后价值进行一项回顾性队列研究。

患者与方法

由于对治疗前、手术前完整血常规检查结果以及放疗期间至少每周一次的严格限制标准，放疗组共纳入158例女性患者。此外，预处理组和术前组共纳入221例患者，其中包括放疗组的158例患者。

结果

放疗期间最低ALC时间点的ALC和PLR是乳腺癌的预后预测指标，较低的ALC和较高的PLR是DFS不良的独立显著预测指标。此外，治疗前和术前较低的ALC、较高的NLR和较高的PLR被发现是预测DFS不良的独立变量。

结论

治疗前、术前和放疗期间的LRBP可能作为乳腺癌预后的预测指标。

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