Liao Chun-Cheng, Sheu Wayne Huey-Herng, Lin Shih-Yi, Lee Wen-Jane, Lee I-Te
Department of Family Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan.
School of Medicine, National Defense Medical Center, Taipei, Taiwan.
Diabetes Metab Syndr Obes. 2020 Jan 6;13:1-8. doi: 10.2147/DMSO.S228954. eCollection 2020.
To assess the relationship between changes in abdominal adipose tissue and metabolic syndrome (MetS) in men with obesity after a weight reduction program (WRP).
Adult men with obesity and MetS were recruited for this prospective single-arm intervention study. Participants consumed an energy-restricted diet of 1200 kcal/day and performed 50-mins aerobic exercise daily for 12 weeks. Changes in the components of MetS were recorded. Changes in subcutaneous abdominal fat area (SAFA) and intra-abdominal fat area (IAFA) at the umbilicus level were determined using magnetic resonance imaging.
A total of 30 men (mean age, 42.3 ± 10.0 years; body mass index, 33.7 ± 4.1 kg/m) were included in this study. A moderate (8.0%) weight reduction occurred. Reversion of MetS was observed in 15 (50%) participants after the WRP. There was significant reduction in SAFA (68.3 ± 20.2 vs. 51.5 ± 18.6 cm; < 0.001) and IAFA (96.3 ± 15.6 vs. 86.0 ± 16.5 cm; < 0.001); the magnitude of reduction was greater for SAFA than for IAFA (-16.8 ± 7.7 vs. -10.3 ± 8.3 cm; < 0.001). Multivariate logistic regression analysis showed a reduction in IAFA to be an independent factor to decrease the risk of persistent MetS after WRP by adjustment for age, baseline IAFA, and change in SAFA (odds ratio = 0.25, 95% confidence interval: 0.07-0.95, = 0.041). Reduction in SAFA was not significantly associated with the reversion of MetS ( = 0.411).
Reduction in IAFA via a 12-week WRP may help reverse MetS in men with obesity and MetS.
评估减重计划（WRP）后肥胖男性腹部脂肪组织变化与代谢综合征（MetS）之间的关系。
招募患有肥胖症和代谢综合征的成年男性参与这项前瞻性单臂干预研究。参与者每天摄入1200千卡的能量限制饮食，并每天进行50分钟的有氧运动，持续12周。记录代谢综合征各组分的变化。使用磁共振成像确定脐水平的皮下腹部脂肪面积（SAFA）和腹内脂肪面积（IAFA）的变化。
本研究共纳入30名男性（平均年龄42.3±10.0岁；体重指数33.7±4.1kg/m）。体重适度减轻了8.0%。WRP后，15名（50%）参与者的代谢综合征得到逆转。SAFA（68.3±20.2 vs. 51.5±18.6cm²；P<0.001）和IAFA（96.3±15.6 vs. 86.0±16.5cm²；P<0.001）均显著减少；SAFA的减少幅度大于IAFA（-16.8±7.7 vs. -10.3±8.3cm²；P<0.001）。多因素逻辑回归分析显示，调整年龄、基线IAFA和SAFA变化后，IAFA的减少是降低WRP后持续性代谢综合征风险的独立因素（比值比=0.25，95%置信区间：0.07-0.95，P=0.041）。SAFA的减少与代谢综合征的逆转无显著相关性（P=0.411）。
通过为期12周的WRP减少IAFA可能有助于逆转肥胖且患有代谢综合征男性的代谢综合征。
