Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O.B. 653, Beer-Sheva, 8410501, Israel.
Nuclear Research Center Negev, P.O.B 9001, Dimona, 84190, Israel.
Clin Nutr. 2017 Jun;36(3):804-811. doi: 10.1016/j.clnu.2016.05.009. Epub 2016 May 27.
BACKGROUND & AIMS: We aimed to assess the association between the distinct abdominal sub-depots and resting energy expenditure (REE).
We performed magnetic resonance imaging (MRI) to quantify abdominal visceral-adipose-tissue (VAT), deep-subcutaneous-adipose-tissue (deep-SAT), and superficial-subcutaneous-adipose-tissue (superficial-SAT). We measured REE by indirect-calorimetry. Non-exercise activity thermogenesis (NEAT) [1-3 metabolic equivalents (METs)] and exercise thermogenesis (activities of 4+MET) were estimated based on 6-days of accelerometry to assess total physical activity energy expenditure (PAEE).
We studied 282 participants: 249 men [mean age = 47.4 years, body-mass-index (BMI) = 31 kg/m, mean VAT proportion from total abdominal fat = 34.5%, mean superficial-SAT proportion from total abdominal fat = 24.3%] and 33 women (mean age = 51.2 years, BMI = 30.1 kg/m, mean VAT proportion from total abdominal fat = 22.8%, mean superficial-SAT proportion from total abdominal fat = 37.8%). As expected, women had lower REE [by 32.4% (1488 ± 234 kcal/day vs. 1971 ± 257 kcal/day; p < 0.01)] and lower REE/kg [by 8% (19.6 ± 3 kcal/kg vs. 21.2 ± 2 kcal/kg; p < 0.01)] than men. Exercise and total PAEE were positively associated with REE/kg (p < 0.01 for both) and a positive correlation between NEAT and REE/kg was borderline (p = 0.056). Participants, in whom abdominal VAT was the dominant proportional depot, had higher REE (1964 ± 297 kcal/day vs. 1654 ± 352 kcal/day; p < 0.01) and higher REE∖kg (22.2 ± 2.3 kcal/kg/day vs. 19.6 ± 2.5 kcal/kg/day; p < 0.01) than participants in whom superficial-SAT was the largest proportional depot. In multivariate models, adjusted for age, gender and residual BMI, increased VAT proportion was independently associated with higher REE (β = 0.181; p = 0.05). Likewise, increased VAT proportion (β = 0.482; p < 0.01) remained independently associated with higher REE/kg. In this model younger age (β = -0.329; p < 0.01) was associated with higher REE/kg.
Abdominal fat distribution patterns are associated with varying levels of resting energy expenditure, potentially reflecting different metabolic rates of adipose sub-depots and providing an anatomic/anthropometric link to physiological obese sub-phenotypes.
我们旨在评估不同腹部亚区与静息能量消耗（REE）之间的关联。
我们通过磁共振成像（MRI）来量化腹部内脏脂肪组织（VAT）、深皮下脂肪组织（deep-SAT）和浅皮下脂肪组织（superficial-SAT）。我们通过间接测热法测量 REE。根据 6 天的加速度计测量，非运动活动产热（NEAT）[1-3 代谢当量（METs）]和运动产热（活动 4+MET）被估计，以评估总体力活动能量消耗（PAEE）。
我们研究了 282 名参与者：249 名男性（平均年龄 47.4 岁，体重指数（BMI）31kg/m，腹部脂肪总量中 VAT 比例为 34.5%，腹部脂肪总量中 superficial-SAT 比例为 24.3%）和 33 名女性（平均年龄 51.2 岁，BMI 30.1kg/m，腹部脂肪总量中 VAT 比例为 22.8%，腹部脂肪总量中 superficial-SAT 比例为 37.8%）。正如预期的那样，女性的 REE[降低 32.4%（1488±234kcal/天比 1971±257kcal/天；p<0.01）]和 REE/kg[降低 8%（19.6±3kcal/kg 比 21.2±2kcal/kg；p<0.01）]均低于男性。运动和总 PAEE 与 REE/kg 呈正相关（两者均为 p<0.01），而 NEAT 与 REE/kg 之间的相关性呈边缘性（p=0.056）。在 VAT 是主要比例性脂肪库的参与者中，REE 更高（1964±297kcal/天比 1654±352kcal/天；p<0.01），REE/kg 更高（22.2±2.3kcal/kg/天比 19.6±2.5kcal/kg/天；p<0.01），高于 superficial-SAT 是最大比例性脂肪库的参与者。在调整年龄、性别和残余 BMI 的多变量模型中，增加的 VAT 比例与更高的 REE 独立相关（β=0.181；p=0.05）。同样，增加的 VAT 比例（β=0.482；p<0.01）与更高的 REE/kg 仍然独立相关。在该模型中，年龄较小（β=-0.329；p<0.01）与更高的 REE/kg 相关。
腹部脂肪分布模式与静息能量消耗的不同水平相关，这可能反映了不同的脂肪亚区代谢率，并为生理肥胖亚表型提供了解剖学/人体测量学的联系。
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