[Effect of consolidation before allogeneic hematopoietic stem cell transplantation for non-favorable acute myeloid leukemia patients with first complete remisson and negative minimal residual disease].

To probe the prognostic value of consolidation chemotherapy in non-favorable acute myeloid leukemia (AML) patients who were candidates for allogeneic hematopoietic stem cell transplantation (allo-HSCT) with first complete remission (CR(1)) and negative minimal residual disease (MRD(-)) . A retrospective analysis was conducted on 155 patients with non-favorable AML who received allo-HSCT in CR(1)/MRD(-) from January 2010 to March 2019. The survival data were compared between patients who received and those not received pre-transplant consolidation chemotherapy. A total of 102 patients received pre-transplant consolidation chemotherapy (consolidation group) , and 53 cases directly proceeded to allo-HSCT when CR(1)/MRD(-) was achieved (nonconsolidation group) . The median ages were 39 (18-56) years old and 38 (19-67) years old, respectively. Five-year post-transplant overall survival [ (59.3±7.5) % (62.2±6.9) %, =0.919] and relapse-free survival [ (53.0±8.9) % (61.6±7.0) %, =0.936] were not significantly different between the two groups (consolidation nonconsolidation) . There was a weak relationship between consolidation therapy and cumulative incidence of relapse [consolidation: (21.9±5.4) % nonconsolidation: (18.3±6.0) %, =0.942], as well as non-relapse mortality [consolidation: (22.4±4.3) % nonconsolidation: (28.4±6.5) %,=0.464]. Multivariate analysis indicated that pre-transplant consolidation and the consolidation courses (< 2 ≥2 courses) did not have an impact on allo-HSCT outcomes. Allo-HSCT for candidate patients without further consolidation when CR(1)/MRD(-) was attained was feasible.