Pistolesi M, Miniati M, Petruzzelli S, Carrozzi L, Giani L, Bellina C R, Gerundini P, Fazio F, Giuntini C
CNR Istituto di Fisiologia Clinica, Pisa, Italy.
Am Rev Respir Dis. 1988 Dec;138(6):1429-33. doi: 10.1164/ajrccm/138.6.1429.
N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine (HIPDM), a synthetic basic compound with high affinity for lung tissue of various animal species, was labeled with 123I and injected into normal smokers (n = 9) and into asymptomatic smokers (n = 9). Time/activity curves were recorded for 90 min by gamma camera. HIPDM lung clearance was described by two exponential components. In smokers, the mean time of the first component, 10 +/- 1.4 min (mean +/- SEM), did not significantly differ from that of nonsmokers (9.7 +/- 0.9 min), whereas the mean time of the second component (12.9 +/- 0.6 h) was longer than that of nonsmokers (6.7 +/- 0.2 h). The intercept to the ordinate of the second exponential component was significantly higher in smokers (90.3 +/- 1.5%) than in nonsmokers (80.7 +/- 1.9%). Control studies in rabbits showed that, 2 min after intravenous injection, 95% of HIPDM is taken up by the lung; time/activity curves were similar to those obtained in humans. The longer pulmonary persistence of HIPDM in smokers may reflect an increased number of cellular binding sites or may be the expression of hindered HIPDM biotransformation. The rabbit can be used as a model to further investigate HIPDM kinetics in relation to lung dysfunction.
N,N,N'-三甲基-N'-(2-羟基-3-甲基-5-碘苄基)-1,3-丙二胺（HIPDM）是一种对多种动物物种的肺组织具有高亲和力的合成碱性化合物，用123I进行标记后注射到正常吸烟者（n = 9）和无症状吸烟者（n = 9）体内。用γ相机记录90分钟的时间/活性曲线。HIPDM的肺清除率由两个指数成分描述。在吸烟者中，第一个成分的平均时间为10±1.4分钟（平均值±标准误），与非吸烟者（9.7±0.9分钟）相比无显著差异，而第二个成分的平均时间（12.9±0.6小时）比非吸烟者（6.7±0.2小时）更长。第二个指数成分与纵坐标的截距在吸烟者中（90.3±1.5%）显著高于非吸烟者（80.7±1.9%）。对兔子的对照研究表明，静脉注射后2分钟，95%的HIPDM被肺摄取；时间/活性曲线与在人类中获得的曲线相似。HIPDM在吸烟者肺部的持续时间更长可能反映了细胞结合位点数量的增加，或者可能是HIPDM生物转化受阻的表现。兔子可作为进一步研究HIPDM与肺功能障碍相关动力学的模型。
