Couture Anne, Lavergne Valéry, Sandman Emilie, Leduc Jean-Michel, Benoit Benoit, Leduc Stéphane, Rouleau Dominique M
Université de Montréal, 2900 Boul., Edouard-Montpetit, Montreal, QC, H3T 1J4, Canada.
Hôpital Du Sacré-Cœur, Montréal, 5400 Boul. Gouin Ouest, Montreal, QC, H4J 1C5, Canada.
J Orthop. 2019 Nov 28;19:138-142. doi: 10.1016/j.jor.2019.11.028. eCollection 2020 May-Jun.
This study explored the efficacy of antibiotics mixed with calcium sulfate (ACS) against
isolates from orthopaedic infection sites were tested for antimicrobial susceptibility with ACS. Minimal inhibitory concentrations (MIC) were determined with a gradient diffusion method (Etest® strips).
When tested with Etest®, all 22 isolates were susceptible to penicillin, ceftriaxone, vancomycin, and two were resistant to clindamycin (MICs of 4 and 8 mg/L). Penicillin and rifampin had the largest inhibition zone diameters.
Antibiotics retained activity against when mixed with calcium sulfate.
本研究探讨了抗生素与硫酸钙（ACS）混合对……的疗效
对来自骨科感染部位的分离株用ACS进行抗菌药敏试验。采用梯度扩散法（Etest®试纸条）测定最低抑菌浓度（MIC）。
用Etest®试纸条检测时，所有22株分离株对青霉素、头孢曲松、万古霉素敏感，2株对克林霉素耐药（MIC分别为4和8mg/L）。青霉素和利福平的抑菌圈直径最大。
抗生素与硫酸钙混合时对……仍有活性。
