高脂血症小鼠品系杂交后代中氧化应激与心脏代谢性状的遗传连锁数据。
Data on genetic linkage of oxidative stress with cardiometabolic traits in an intercross derived from hyperlipidemic mouse strains.
作者信息
Fuller Daniela T, Grainger Andrew T, Manichaikul Ani, Shi Weibin
机构信息
Department of Radiology & Medical Imaging, University of Virginia, Charlottesville, VA, USA.
Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, VA, USA.
出版信息
Data Brief. 2020 Jan 23;29:105165. doi: 10.1016/j.dib.2020.105165. eCollection 2020 Apr.
The data presented here are related to the research article, entitled Genetic linkage of oxidative stress with cardiometabolic traits in an intercross derived from hyperlipidemic mouse strains, published in Atherosclerosis 2019 Dec 3;293:1-10 (D. Fuller, A.T. Grainger, A. Manichaikul, W. Shi). The supporting materials include original genotypic and phenotypic data obtained from 266 female F2 mice derived from an intercross between C57BL/6 (B6) and BALB/cJ (BALB) Apoe mice. F2 mice were fed 12 weeks of Western diet, starting at 6 weeks of age. Plasma levels of HDL, LDL cholesterol, triglycerides, glucose and malondialdehyde (MDA) and atherosclerosis in the aortic root and the left carotid artery were measured. 127 microsatellite markers across the entire genome were genotyped. The data is provided in the format ready for QTL analysis with J/qtl and MapManager QTX.
此处呈现的数据与一篇研究文章相关，该文章题为《高脂血症小鼠品系杂交后代中氧化应激与心脏代谢性状的遗传连锁》，发表于《动脉粥样硬化》2019年12月3日；第293卷：第1 - 10页（D. 富勒、A.T. 格兰杰、A. 马尼柴库尔、W. 施）。支持材料包括从266只雌性F2小鼠获得的原始基因型和表型数据，这些小鼠源自C57BL/6（B6）和BALB/cJ（BALB）载脂蛋白E小鼠的杂交。F2小鼠在6周龄时开始接受为期12周的西式饮食。测量了血浆中高密度脂蛋白、低密度脂蛋白胆固醇、甘油三酯、葡萄糖和丙二醛（MDA）的水平以及主动脉根部和左颈动脉的动脉粥样硬化情况。对整个基因组中的127个微卫星标记进行了基因分型。数据以适合使用J/qtl和MapManager QTX进行数量性状基因座（QTL）分析的格式提供。
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