Eco-friendly approach to access of quinoxaline derivatives using nanostructured pyrophosphate NaPdPO as a new, efficient and reusable heterogeneous catalyst.

In the present study, we report the synthesis of various quinoxaline derivatives from direct condensation of substituted aromatic 1,2-diamine with 1,2-dicarbonyl catalyzed by nanostructured pyrophosphate NaPdPO as a new highly efficient bifunctionalheterogeneous catalyst. The quinoxaline synthesis was performed in ethanol as a green and suitable solvent at ambient temperature to afford the desired quinoxalines with good to excellent yields in shorter reaction times. Many Quinoxaline derivatives were successfully synthesized using various 1,2-diketones and 1,2-diamines at room temperature. Catalyst reusability showed that the NaPdPO catalyst exhibited excellent recyclability without significant loss in its catalytic activity after five consecutive cycles.