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使用纳米结构焦磷酸盐NaPdPO作为新型、高效且可重复使用的多相催化剂，以环保方式合成喹喔啉衍生物。

Eco-friendly approach to access of quinoxaline derivatives using nanostructured pyrophosphate NaPdPO as a new, efficient and reusable heterogeneous catalyst.

作者信息

Dânoun Karim, Essamlali Younes, Amadine Othmane, Mahi Hassan, Zahouily Mohamed

机构信息

1Moroccan Foundation for Advanced Science, Innovation and Research (MAScIR), VARENA Center, Rue Mohamed El Jazouli, Madinat Al Irfane, 10100 Rabat, Morocco.

2University Hassan II Casablanca, FST Mohammedia, Laboratory of Materials, Catalysis and Valorization of Natural Resources - URAC 24, B.P. 146, 20650 Casablanca, Morocco.

出版信息

BMC Chem. 2020 Feb 3;14(1):6. doi: 10.1186/s13065-020-0662-z. eCollection 2020 Dec.

DOI:10.1186/s13065-020-0662-z
PMID:32025664
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6996184/
Abstract

In the present study, we report the synthesis of various quinoxaline derivatives from direct condensation of substituted aromatic 1,2-diamine with 1,2-dicarbonyl catalyzed by nanostructured pyrophosphate NaPdPO as a new highly efficient bifunctionalheterogeneous catalyst. The quinoxaline synthesis was performed in ethanol as a green and suitable solvent at ambient temperature to afford the desired quinoxalines with good to excellent yields in shorter reaction times. Many Quinoxaline derivatives were successfully synthesized using various 1,2-diketones and 1,2-diamines at room temperature. Catalyst reusability showed that the NaPdPO catalyst exhibited excellent recyclability without significant loss in its catalytic activity after five consecutive cycles.

摘要

在本研究中，我们报道了以纳米结构焦磷酸盐NaPdPO作为一种新型高效双功能非均相催化剂，通过取代芳族1,2 - 二胺与1,2 - 二羰基的直接缩合反应合成各种喹喔啉衍生物。喹喔啉的合成在乙醇这种绿色且合适的溶剂中于室温下进行，以便在较短的反应时间内以良好至优异的产率得到所需的喹喔啉。在室温下使用各种1,2 - 二酮和1,2 - 二胺成功合成了许多喹喔啉衍生物。催化剂的可重复使用性表明，NaPdPO催化剂表现出优异的可回收性，在连续五个循环后其催化活性没有明显损失。

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