Timmermans L M, Canon E, Timmermans L G
Département d'Urologie, CHU A Vésale, Montignies-Le-Tilleul.
Ann Urol (Paris). 1988;22(5):351-3.
In eleven non-diabetic women suffering from high compliance bladder, the authors correlate urodynamic findings with the modifications of the autonomic vesical innervation. Endoscopic biopsies show a dramatic reduction in acetylcholinesterase-positive innervation in the detrusor but less visible in the trigone. The adrenergic network density is also reduced in both areas, according to age. Congenital conditions, high pressure mechanisms, vascular hypoxia explain these autonomic alterations inducing iatrogenic problems associated with different drug treatments. In some cases, urethral hypertonic instability acts in the same way as mechanical obstruction.
在11名患有高顺应性膀胱的非糖尿病女性中，作者将尿动力学检查结果与膀胱自主神经支配的改变进行了关联。内镜活检显示，逼尿肌中乙酰胆碱酯酶阳性神经支配显著减少，但在三角区不太明显。根据年龄，两个区域的肾上腺素能网络密度也降低。先天性疾病、高压机制、血管缺氧解释了这些自主神经改变，这些改变会引发与不同药物治疗相关的医源性问题。在某些情况下，尿道高张性不稳定的作用方式与机械性梗阻相同。
