与单纯使用丙泊酚相比，在接受腹腔镜妇科手术的患者中，低浓度七氟醚与丙泊酚联合使用不会增加术后恶心呕吐的发生率。
Incidence of postoperative nausea and vomiting is not increased by combination of low concentration sevoflurane and propofol compared with propofol alone in patients undergoing laparoscopic gynecological surgery.
作者信息
Uchinami Yuka, Takikawa Satoshi, Takashima Fumiki, Maeda Yosuke, Nasu Satoki, Ito Ayumi, Saito Tatushi
机构信息
Department of Anesthesiology, Hakodate Central General Hospital, 3-2, Honcho3, Hakodate, 040-8585, Japan.
出版信息
JA Clin Rep. 2019 Nov 2;5(1):70. doi: 10.1186/s40981-019-0292-4.
BACKGROUND
The incidence of postoperative nausea and vomiting (PONV) is higher in patients receiving volatile anesthetics than those receiving total intravenous anesthesia (TIVA) with propofol. However, it is unclear whether its incidence is increased when a low concentration of sevoflurane is used in combination with propofol.
METHODS
This prospective, randomized, controlled trial enrolled women undergoing laparoscopic gynecological surgery. Patients were randomly assigned to receive general anesthesia either with propofol alone (group P) or with 0.8% sevoflurane and propofol (group SP, n = 36, each group) for maintenance of anesthesia. The incidence of PONV and the number of patients who required antiemetics were compared.
RESULTS
There were no differences in the incidence of PONV and the number of patients who required antiemetics between the P and SP groups.
CONCLUSIONS
A combination of 0.8% sevoflurane and propofol to maintain anesthesia does not increase the incidence of PONV compared with TIVA with propofol.
TRIAL REGISTRATION
UMIN-CTR UMIN000023647 , registered 14 August 2016.
背景
接受挥发性麻醉剂的患者术后恶心呕吐（PONV）的发生率高于接受丙泊酚全静脉麻醉（TIVA）的患者。然而，低浓度七氟醚与丙泊酚联合使用时，其发生率是否会增加尚不清楚。
方法
这项前瞻性、随机、对照试验纳入了接受腹腔镜妇科手术的女性患者。患者被随机分配接受单纯丙泊酚全身麻醉（P组）或0.8%七氟醚与丙泊酚联合全身麻醉（SP组，每组n = 36）以维持麻醉。比较PONV的发生率和需要使用止吐药的患者数量。
结果
P组和SP组之间PONV的发生率和需要使用止吐药的患者数量没有差异。
结论
与丙泊酚TIVA相比，0.8%七氟醚与丙泊酚联合维持麻醉不会增加PONV的发生率。
试验注册
UMIN-CTR UMIN000023647，于2016年8月14日注册。
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