Ng P C, Dear P R, Thomas D F
Department of Paediatrics and Child Health, St James's University Hospital, Leeds.
Arch Dis Child. 1988 Nov;63(11):1390-3. doi: 10.1136/adc.63.11.1390.
Eighty four very low birthweight babies (considered high risk for developing necrotising enterocolitis) were given vancomycin orally for 48 hours before introduction of oral feeds; one developed necrotising enterocolitis. One hundred and twenty very low birthweight babies (not considered such high risk) were fed without first receiving vancomycin; 17 developed necrotising enterocolitis. Although this was not a randomised control trial, results indicate a role for vancomycin in prophylaxis of necrotising enterocolitis.
84名极低出生体重儿（被认为发生坏死性小肠结肠炎的高危人群）在开始经口喂养前口服万古霉素48小时；其中1名发生了坏死性小肠结肠炎。120名极低出生体重儿（未被认为是如此高危）未先接受万古霉素治疗即开始喂养；17名发生了坏死性小肠结肠炎。尽管这不是一项随机对照试验，但结果表明万古霉素在预防坏死性小肠结肠炎方面有作用。
