"Beit Rivka" Geriatric Rehabilitation Center, Petah Tikva, Israel.
Tel Aviv University, Israel.
J Appl Gerontol. 2021 Jun;40(6):661-669. doi: 10.1177/0733464820904564. Epub 2020 Feb 6.
Antipsychotic (AP) use may lead to numerous side effects which may affect rehabilitation outcomes. A retrospective cohort study was carried out on 448 hip fractured patients admitted to a post-acute geriatric rehabilitation center. Functional improvement was measured by the Functional Independence Measure (FIM), motor FIM (mFIM), and mFIM effectiveness. A multiple linear regression model and regression analysis was used to evaluate the level of association between AP use and achievement of favorable functional gain. AP users exhibited lower functional ability on admission and at discharge, achieved a significantly lower functional gain and required longer rehabilitation time compared with nonusers. AP use by post-acute hip fractured patients negatively affects their chances of achieving favorable rehabilitation outcome after adjustment for confounders.
抗精神病药物（AP）的使用可能会导致许多副作用，从而影响康复结果。我们对入住一家老年康复中心的 448 名髋部骨折患者进行了回顾性队列研究。通过功能独立性测量（FIM）、运动 FIM（mFIM）和 mFIM 效果来衡量功能改善情况。采用多元线性回归模型和回归分析评估抗精神病药物使用与实现有利功能增益之间的关联程度。与非使用者相比，使用抗精神病药物的患者在入院时和出院时的功能能力较低，实现的功能增益明显较低，需要的康复时间更长。调整混杂因素后，髋部骨折患者在急性期后使用抗精神病药物会降低其获得有利康复结果的机会。
