[Histological and cytological characteristics of structural changes of the endometrium of guinea pigs in health and in experimental glandular hyperplasia].

An experiment on 203 guinea-pigs involved morphometric and cytological evaluation of morphofunctional profile of the endometrium and vaginal epithelium at various stages of the estrous cycle and endometrial glandular hyperplasia development. The results permitted the authors to establish morphometric and cytological criteria of estrogenic saturation of the organism, to reveal features of hyperplasia in paired and unpaired uterine parts in experimental exogenic hyperestrogenism. There appeared a correlation between variations in the cytological indices of the vaginal smear and the severity of endometrial hyperplastic process. The tendencies observed for quantitative indices warrant intravital evaluation of the formation of the experimental glandular endometrial hyperplasia and objective assessment of the test treatments.