Khmel'nitskiĭ O k, Li L N, Danilenko A I, Zaporozhan V N, Khait O V
Arkh Patol. 1988;50(9):60-8.
An experiment on 203 guinea-pigs involved morphometric and cytological evaluation of morphofunctional profile of the endometrium and vaginal epithelium at various stages of the estrous cycle and endometrial glandular hyperplasia development. The results permitted the authors to establish morphometric and cytological criteria of estrogenic saturation of the organism, to reveal features of hyperplasia in paired and unpaired uterine parts in experimental exogenic hyperestrogenism. There appeared a correlation between variations in the cytological indices of the vaginal smear and the severity of endometrial hyperplastic process. The tendencies observed for quantitative indices warrant intravital evaluation of the formation of the experimental glandular endometrial hyperplasia and objective assessment of the test treatments.
一项针对203只豚鼠的实验，涉及对发情周期不同阶段子宫内膜和阴道上皮的形态功能特征以及子宫内膜腺体增生发展情况进行形态计量学和细胞学评估。研究结果使作者能够确立机体雌激素饱和的形态计量学和细胞学标准，揭示实验性外源性雌激素过多症中子宫成对和不成对部分增生的特征。阴道涂片细胞学指标的变化与子宫内膜增生过程的严重程度之间存在相关性。所观察到的定量指标趋势有助于对实验性腺体子宫内膜增生的形成进行活体评估，并对受试治疗进行客观评估。
