Institute of Neuroscience and Medicine (INM-3), Research Centre Juelich.
Faculty of Medicine and University Hospital Cologne, University of Cologne.
J Cogn Neurosci. 2020 Jun;32(6):1130-1141. doi: 10.1162/jocn_a_01543. Epub 2020 Feb 6.
Although multiple studies characterized the resting-state functional connectivity (rsFC) of the right temporoparietal junction (rTPJ), little is known about the link between rTPJ rsFC and cognitive functions. Given a putative involvement of rTPJ in both reorienting of attention and the updating of probabilistic beliefs, this study characterized the relationship between rsFC of rTPJ with dorsal and ventral attention systems and these two cognitive processes. Twenty-three healthy young participants performed a modified location-cueing paradigm with true and false prior information about the percentage of cue validity to assess belief updating and attentional reorienting. Resting-state fMRI was recorded before and after the task. Seed-based correlation analysis was employed, and correlations of each behavioral parameter with rsFC before the task, as well as with changes in rsFC after the task, were assessed in an ROI-based approach. Weaker rsFC between rTPJ and right intraparietal sulcus before the task was associated with relatively faster updating of the belief that the cue will be valid after false prior information. Moreover, relatively faster belief updating, as well as faster reorienting, were related to an increase in the interhemispheric rsFC between rTPJ and left TPJ after the task. These findings are in line with task-based connectivity studies on related attentional functions and extend results from stroke patients demonstrating the importance of interhemispheric parietal interactions for behavioral performance. The present results not only highlight the essential role of parietal rsFC for attentional functions but also suggest that cognitive processing during a task changes connectivity patterns in a performance-dependent manner.
尽管多项研究对右侧颞顶联合区（rTPJ）的静息态功能连接（rsFC）进行了描述，但 rTPJ 的 rsFC 与认知功能之间的联系仍知之甚少。鉴于 rTPJ 可能同时参与注意力的重新定向和概率信念的更新，本研究描述了 rTPJ 的 rsFC 与背侧和腹侧注意系统以及这两个认知过程之间的关系。23 名健康的年轻参与者进行了一项改良的位置提示范式，该范式包含关于提示有效性的真实和虚假先验信息，以评估信念更新和注意力的重新定向。在任务前后记录了静息态 fMRI。采用基于种子的相关分析，在基于 ROI 的方法中评估了每个行为参数与任务前 rsFC 的相关性，以及与任务后 rsFC 变化的相关性。任务前 rTPJ 与右侧顶内沟之间较弱的 rsFC 与在错误先验信息后对提示有效的信念的相对快速更新相关。此外，相对较快的信念更新以及较快的重新定向与任务后 rTPJ 与左侧 TPJ 之间的半球间 rsFC 的增加有关。这些发现与关于相关注意力功能的基于任务的连接研究一致，并扩展了来自中风患者的结果，表明半球间顶叶相互作用对于行为表现的重要性。这些结果不仅突出了顶叶 rsFC 对注意力功能的重要作用，还表明认知处理在任务中会以依赖于性能的方式改变连接模式。
