Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, 08901, USA.
Graduate School of Biomedical Science, Rutgers University, Piscataway, NJ, 08854, USA.
J Steroid Biochem Mol Biol. 2020 May;199:105616. doi: 10.1016/j.jsbmb.2020.105616. Epub 2020 Feb 3.
To evaluate the measured free 25-hydroxyvitamin D [25(OH)D] levels in patients with hyperparathyroidism (PHPT) and healthy controls. Eighty patients with PHPT(n = 40) and age and BMI matched controls (n = 40) were examined. Serum levels of total or free 25(OH)D, vitamin D binding protein (DBP), intact parathyroid hormone (iPTH) and calcium were measured. There was no significant difference in age (61.2 ± 11.9 vs 60.2 ± 7.0 years) and BMI (30.0 ± 6.1 vs 30.0 ± 2.2 kg/m) between PHPT patients and healthy subjects. Levels of total 25(OH)D were about 20 % lower in PHPT patients (26.4 ± 7.7 ng/mL) compared to controls (31.0 ± 7.8 ng/mL, P < 0.05). There were no significant differences in calculated or measured free 25(OH)D levels between PHPT patients (4.9 ± 1.8 or 4.9 ± 1.6 pg/mL, respectively) and control subjects (5.1 ± 1.2 or 5.3 ± 1.6 pg/mL, respectively). Levels of free 25(OH)D were positively associated with levels of total 25(OH)D (r = 0.28, P < 0.05) but negatively correlated with iPTH and calcium levels (r=-0.22 and -0.23 respectively, P < 0.05). Serum total 25(OH)D levels were lower but the calculated or measured free 25(OH)D levels in patients with PHPT did not differ from healthy subjects. We suggest that total 25(OH)D levels may not reflect true vitamin D nutritional status in patients with PHPT.
评估甲状旁腺功能亢进症 (PHPT) 患者和健康对照者的游离 25-羟维生素 D [25(OH)D] 实测值。共检查 80 例 PHPT 患者(n = 40)和年龄、BMI 匹配的对照组(n = 40)。测定血清总或游离 25(OH)D、维生素 D 结合蛋白(DBP)、全段甲状旁腺激素(iPTH)和钙水平。PHPT 患者与健康受试者的年龄(61.2 ± 11.9 岁比 60.2 ± 7.0 岁)和 BMI(30.0 ± 6.1 千克/平方米比 30.0 ± 2.2 千克/平方米)无显著差异。PHPT 患者的总 25(OH)D 水平较对照组低约 20%(26.4 ± 7.7 纳克/毫升比 31.0 ± 7.8 纳克/毫升，P < 0.05)。PHPT 患者(4.9 ± 1.8 或 4.9 ± 1.6 皮克/毫升，分别)和对照组(5.1 ± 1.2 或 5.3 ± 1.6 皮克/毫升，分别)的计算或实测游离 25(OH)D 水平无显著差异。游离 25(OH)D 水平与总 25(OH)D 水平呈正相关(r = 0.28，P < 0.05)，但与 iPTH 和钙水平呈负相关(r =-0.22 和-0.23，P < 0.05)。PHPT 患者的血清总 25(OH)D 水平较低，但计算或实测游离 25(OH)D 水平与健康受试者无差异。我们认为，PHPT 患者的总 25(OH)D 水平可能不能反映真实的维生素 D 营养状态。
