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欧洲院外心脏骤停后的生存率——EuReCa TWO研究结果

Survival after out-of-hospital cardiac arrest in Europe - Results of the EuReCa TWO study.

作者信息

Gräsner Jan-Thorsten, Wnent Jan, Herlitz Johan, Perkins Gavin D, Lefering Rolf, Tjelmeland Ingvild, Koster Rudolph W, Masterson Siobhán, Rossell-Ortiz Fernando, Maurer Holger, Böttiger Bernd W, Moertl Maximilian, Mols Pierre, Alihodžić Hajriz, Hadžibegović Irzal, Ioannides Marios, Truhlář Anatolij, Wissenberg Mads, Salo Ari, Escutnaire Josephine, Nikolaou Nikolaos, Nagy Eniko, Jonsson Bergthor Steinn, Wright Peter, Semeraro Federico, Clarens Carlo, Beesems Steffie, Cebula Grzegorz, Correia Vitor H, Cimpoesu Diana, Raffay Violetta, Trenkler Stefan, Markota Andrej, Strömsöe Anneli, Burkart Roman, Booth Scott, Bossaert Leo

机构信息

University-Hospital Schleswig-Holstein, Institute for Emergency Medicine, Kiel, Germany; University-Hospital Schleswig-Holstein, Department of Anesthesiology and Intensive Care Medicine, Kiel, Germany.

University-Hospital Schleswig-Holstein, Institute for Emergency Medicine, Kiel, Germany; University-Hospital Schleswig-Holstein, Department of Anesthesiology and Intensive Care Medicine, Kiel, Germany; University of Namibia, School of Medicine, Windhoek, Namibia.

出版信息

Resuscitation. 2020 Mar 1;148:218-226. doi: 10.1016/j.resuscitation.2019.12.042. Epub 2020 Feb 3.

Abstract

BACKGROUND

The epidemiology and outcome after out-of-hospital cardiac arrest (OHCA) varies across Europe. Following on from EuReCa ONE, the aim of this study was to further explore the incidence of and outcomes from OHCA in Europe and to improve understanding of the role of the bystander.

METHODS

This prospective, multicentre study involved the collection of registry-based data over a three-month period (1st October 2017 to 31st December 2017). The core study dataset complied with the Utstein-style. Primary outcomes were return of spontaneous circulation (ROSC) and survival to hospital admission. Secondary outcome was survival to hospital discharge.

RESULTS

All 28 countries provided data, covering a total population of 178,879,118. A total of 37,054 OHCA were confirmed, with CPR being started in 25,171 cases. The bystander cardiopulmonary resuscitation (CPR) rate ranged from 13% to 82% between countries (average: 58%). In one third of cases (33%) ROSC was achieved and 8% of patients were discharged from hospital alive. Survival to hospital discharge was higher in patients when a bystander performed CPR with ventilations, compared to compression-only CPR (14% vs. 8% respectively).

CONCLUSION

In addition to increasing our understanding of the role of bystander CPR within Europe, EuReCa TWO has confirmed large variation in OHCA incidence, characteristics and outcome, and highlighted the extent to which OHCA is a public health burden across Europe. Unexplained variation remains and the EuReCa network has a continuing role to play in improving the quality management of resuscitation.

摘要

背景

院外心脏骤停(OHCA)的流行病学情况及预后在欧洲各国有所不同。继欧洲院外心脏骤停研究(EuReCa)一期之后,本研究旨在进一步探究欧洲OHCA的发病率及预后情况,并加深对旁观者作用的理解。

方法

这项前瞻性多中心研究在三个月期间(2017年10月1日至2017年12月31日)收集基于登记处的数据。核心研究数据集符合乌斯坦风格。主要结局为自主循环恢复(ROSC)及存活至入院。次要结局为存活至出院。

结果

所有28个国家均提供了数据,覆盖总人口178,879,118。共确诊37,054例OHCA,其中25,171例开始进行心肺复苏。各国旁观者心肺复苏(CPR)率在13%至82%之间(平均:58%)。三分之一的病例(33%)实现了ROSC,8%的患者存活出院。与仅进行胸外按压的CPR相比,旁观者进行通气CPR时患者存活至出院的比例更高(分别为14%和8%)。

结论

除了加深我们对欧洲旁观者CPR作用的理解外,欧洲院外心脏骤停研究(EuReCa)二期还证实了OHCA发病率、特征及预后存在很大差异,并凸显了OHCA在整个欧洲作为公共卫生负担的程度。仍存在无法解释的差异,EuReCa网络在改善复苏质量管理方面仍可继续发挥作用。

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