Kang Seung-Gul, Cho Seo-Eun, Na Kyoung-Sae, Lee Jung Sun, Joo Sung Woo, Cho Seong-Jin, Son Young-Don, Lee Yu Jin
Department of Psychiatry, Gachon University College of Medicine, Incheon, Republic of Korea.
Department of Psychiatry, Gil Medical Center, Incheon, Republic of Korea.
Psychiatry Res Neuroimaging. 2020 Jan 25;297:111032. doi: 10.1016/j.pscychresns.2020.111032.
The neurobiological causes underlying suicidal behaviors in major depressive disorder (MDD) have not been identified. This study was performed to investigate the differences in brain cortical thickness, surface area, and volume between suicide attempters and non-attempters with MDD. We performed magnetic resonance imaging (MRI) in 38 MDD patients (18-65 years old; 18 male, 20 female) with and without a history of suicide attempts. FreeSurfer software was used to compare the cortical thickness, surface area, and volume of 19 suicide attempters with MDD and 19 suicide non-attempters with MDD, while controlling for age, sex, mean area (or volume), and severity of depression. Compared with suicide non-attempters, suicide attempters with MDD exhibited a larger surface area in the left postcentral area and left lateral occipital area and a larger cortical volume in the left postcentral area and left lateral orbitofrontal area. Suicide attempters exhibited a smaller surface area in the left superior frontal area than suicide non-attempters. The present findings provide evidence for neuroanatomical risk factors of suicide in MDD. Further research to replicate these results and determine the mechanisms underlying these findings is needed.
重度抑郁症（MDD）患者自杀行为背后的神经生物学原因尚未明确。本研究旨在调查有自杀未遂史和无自杀未遂史的MDD患者在脑皮质厚度、表面积和体积方面的差异。我们对38例年龄在18至65岁之间（男性18例，女性20例）、有或无自杀未遂史的MDD患者进行了磁共振成像（MRI）检查。使用FreeSurfer软件比较19例有自杀未遂史的MDD患者和19例无自杀未遂史的MDD患者的皮质厚度、表面积和体积，同时控制年龄、性别、平均面积（或体积）和抑郁严重程度。与无自杀未遂史的患者相比，有自杀未遂史的MDD患者在左侧中央后回区域和左侧枕叶外侧区域的表面积更大，在左侧中央后回区域和左侧眶额外侧区域的皮质体积更大。有自杀未遂史的患者在左侧额上回区域的表面积比无自杀未遂史的患者更小。本研究结果为MDD患者自杀的神经解剖学危险因素提供了证据。需要进一步研究以重复这些结果并确定这些发现背后的机制。
