Faculty of Medicine, Hebrew University, Jerusalem, Israel.
Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel.
Am J Perinatol. 2021 Jul;38(9):930-934. doi: 10.1055/s-0040-1701193. Epub 2020 Feb 6.
This study aimed to test whether neonatal hypoglycemia (NH) is more common in infants with neonatal polycythemia (NP).
This is a retrospective study based on universal screening of NH and targeted screening for NP. Polycythemia was defined as venous hematocrit ≥ 65%. NH was defined as whole blood glucose (BG) concentration < 48 mg/dL (measured using a "point-of-care" analyzer [Accu-Chek]).
The study population consisted of 119 consecutive term polycythemic infants and 117 controls. There were no significant differences between the two groups in perinatal characteristics, minimal BG concentration, and rate of hypoglycemia. In a stepwise backward multiple regression where NH was the dependent variable, only maternal gestational diabetes mellitus ( = 0.032) and toxemia ( = 0.001) remained significant, whereas NP was insignificant.
NH is not more common in NP infants than in non-NP infants. We suggest that the occurrence of NH in infants with NP might be related to the common risk factors of the two morbidities.
本研究旨在检验新生儿高红细胞症（NP）是否更易导致新生儿低血糖（NH）。
这是一项基于 NH 普遍筛查和 NP 针对性筛查的回顾性研究。高红细胞症定义为静脉血细胞比容≥65%。NH 定义为全血血糖（BG）浓度＜48mg/dL（使用“即时检测”分析仪[Accu-Chek]测量）。
研究人群包括 119 例连续足月高红细胞症婴儿和 117 例对照。两组在围产期特征、最低 BG 浓度和低血糖发生率方面无显著差异。在以 NH 为因变量的逐步向后多元回归中，只有母亲妊娠期糖尿病（ = 0.032）和毒血症（ = 0.001）仍有显著意义，而 NP 则无显著意义。
NP 婴儿的 NH 并不比非 NP 婴儿更常见。我们认为，NP 婴儿发生 NH 可能与这两种疾病的共同危险因素有关。
