有机催化芳基乙二醛与羟丙酮的不对称Aldol 反应：2,3-二羟基-1,4-二酮的对映选择性合成。
Organocatalytic Asymmetric Aldol Reaction of Arylglyoxals and Hydroxyacetone: Enantioselective Synthesis of 2,3-Dihydroxy-1,4-diones.
机构信息
Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
出版信息
Molecules. 2020 Feb 3;25(3):648. doi: 10.3390/molecules25030648.
Abstract
A highly efficient quinine-derived primary-amine-catalyzed asymmetric aldol addition of hydroxyacetone to arylglyoxals is described. Structurally diverse -2,3-dihydroxy-1,4-diones were generated in high yields, with good diastereoselectivities and enantioselectivities.
摘要
本文描述了一种高效的奎宁衍生的伯胺催化的不对称羟醛加成反应，该反应将羟基丙酮与芳基乙二醛进行加成。反应生成了结构多样的-2,3-二羟基-1,4-二酮，具有较高的产率、良好的非对映选择性和对映选择性。
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