Lee Jiyun, Park Chan Kee, Jung Kyoung In
Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
J Clin Med. 2020 Feb 3;9(2):416. doi: 10.3390/jcm9020416.
To compare the effects of aqueous suppressants (AS) and prostaglandin (PG) analogs during the hypertensive phase on intraocular pressure (IOP) and surgical outcomes.
In this retrospective, observational study, 66 eyes (66 patients) with Ahmed glaucoma valve (AGV) implantation were included. As evaluation items, IOP changes, number of postoperative medications, the surgical success rate, and postoperative complications were examined. Complete success was defined as IOP between 6 and 21 mmHg without medications, while qualified success was with a maximum of four medications.
The short-term IOP reduction following initial medication was 9.3 mmHg for AS and 4.4 mmHg for PG analogs ( = 0.016). More postoperative medications were used in PG than in AS from postoperative 3 months to 3 years (all < 0.05). The qualified success rate with the initial medication was higher in AS than in PG (67.5% vs. 42.3% at 1 year, 80.6% vs. 37.5% at 2 years, 80.0% vs. 35.0% at 3 years, all < 0.05).
Association between AS used as the first medications during the hypertensive phase and better IOP control and a higher success rate was observed. The type of the initial glaucoma medication after AGV implantation could affect short- and long-term surgical outcomes.
比较房水生成抑制剂（AS）和前列腺素（PG）类似物在高血压期对眼压（IOP）及手术效果的影响。
在这项回顾性观察研究中，纳入了66例植入艾哈迈德青光眼引流阀（AGV）的患者（66只眼）。作为评估项目，检查眼压变化、术后用药数量、手术成功率及术后并发症。完全成功定义为不用药时眼压在6至21 mmHg之间，合格成功定义为最多使用四种药物。
初始用药后短期眼压降低幅度，AS组为9.3 mmHg，PG类似物组为4.4 mmHg（ = 0.016）。术后3个月至3年，PG组使用的术后药物比AS组多（均 < 0.05）。初始用药的合格成功率，AS组高于PG组（1年时分别为67.5%对42.3%，2年时为80.6%对37.5%，3年时为80.0%对35.0%，均 < 0.05）。
观察到高血压期将AS作为首选用药与更好的眼压控制及更高的成功率之间存在关联。AGV植入术后初始青光眼用药类型可能影响短期和长期手术效果。
