Zins Karin, Abraham Dietmar
Center for Anatomy and Cell Biology, Division of Cell and Developmental Biology, Medical University of Vienna, 1090 Vienna, Austria.
Cancers (Basel). 2020 Feb 3;12(2):342. doi: 10.3390/cancers12020342.
Macrophages form a major component of the leukocyte infiltrate in solid tumors and it has become increasingly clear that tumor-associated macrophages (TAMs) have tumor-promoting effects within the stroma [1]. Renal cell carcinoma (RCC) solid tumors are comprised of a heterogeneous microenvironment of both malignant and normal stromal cells containing large numbers of macrophages [2].We read with interest the paper by Suguru Kadomoto et al. entitled "Tumor-associated macrophages induce migration of renal cell carcinoma cells via activation of the CCL20-CCR6 axis", published in [3], in which they report that the CCL20-CCR6 axis induces migration and epithelial-mesenchymal transition (EMT) of ACHN and Caki-1 RCC cells in co-cultures with THP-1/U937-derived tumor conditioned macrophages.[...].
巨噬细胞是实体瘤中白细胞浸润的主要组成部分，并且越来越清楚的是，肿瘤相关巨噬细胞（TAM）在基质中具有促进肿瘤的作用[1]。肾细胞癌（RCC）实体瘤由恶性和正常基质细胞组成的异质微环境构成，其中含有大量巨噬细胞[2]。我们饶有兴趣地阅读了菅本亮等人发表的题为“肿瘤相关巨噬细胞通过激活CCL20-CCR6轴诱导肾癌细胞迁移”的论文[3]，他们在论文中报告称，在与THP-1/U937来源的肿瘤条件巨噬细胞共培养时，CCL20-CCR6轴诱导ACHN和Caki-1肾癌细胞迁移和上皮-间质转化（EMT）。[……]
