Tanriverdi Ozgur, Tarimer Mehmet Levent, Pak Ceren Deniz, Uylas Selcuk, Alkan Ali, Dere Yelda, Yazici Ayse, Sen Serdar, Sahin Hayrettin
Department of Medical Oncology, Mugla Sitki Koçman University Faculty of Medicine, Mugla, Turkey.
Mugla Sitki Koçman University Faculty of Medicine, Mugla, Turkey.
J Oncol Pharm Pract. 2020 Sep;26(6):1520-1523. doi: 10.1177/1078155220903374. Epub 2020 Feb 6.
Mucinous adenocarcinomas of the testicular surface epithelial tumors are very rare and are similar to malignant ovarian-type surface epithelial tumors. Although only 32 cases have been reported to date, there are only five cases of primary testicular mucinous carcinoma with access to literature in English. So there is still limited information about clinical, etiopathogenesis and treatment options.
In this article, we discuss a 56-year-old male patient diagnosed with testicular mucinous adenocarcinoma due to its rarity in the light of literature review. We preferred cisplatin-paclitaxel regimen for adjuvant treatment. We then used sequential treatments including oxaliplatin, 5-fluorourasil, etoposide, gemcitabine, and docetaxel to treat metastatic disease. The patient underwent lung metastasectomy for the first relapse. The patient was diagnosed in November 2013 and the response to treatment was evaluated in December 2019 and stable disease was detected. The patient, who has a total survival of 73 months, is still under treatment.
Excluding malign transformation and borderline mucinous testicular tumors from mucinous cystadenomas of the testis, the knowledge on carcinogenesis, clinical course, and treatment of primary testicular mucinous adenocarcinomas is very limited.
睾丸表面上皮肿瘤中的黏液性腺癌非常罕见，与恶性卵巢型表面上皮肿瘤相似。尽管迄今为止仅报道了32例，但仅有5例原发性睾丸黏液癌的英文文献可供查阅。因此，关于其临床、病因发病机制及治疗选择的信息仍然有限。
在本文中，鉴于其罕见性，我们结合文献复习讨论了一名56岁被诊断为睾丸黏液性腺癌的男性患者。我们选择顺铂 - 紫杉醇方案进行辅助治疗。然后我们使用包括奥沙利铂、5 - 氟尿嘧啶、依托泊苷、吉西他滨和多西他赛的序贯治疗来治疗转移性疾病。患者首次复发时接受了肺转移瘤切除术。该患者于2013年11月确诊，2019年12月评估治疗反应时发现疾病稳定。该患者总生存期为73个月，仍在接受治疗。
排除睾丸黏液性囊腺瘤的恶性转化和交界性黏液性睾丸肿瘤后，关于原发性睾丸黏液性腺癌的致癌作用、临床病程及治疗的知识非常有限。
