Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271016, Shandong, China.
Biomed Environ Sci. 2020 Jan 20;33(1):11-18. doi: 10.3967/bes2020.002.
The aims of this study were to assess the associations between parity and metabolic syndrome (MetS) and its components and to evaluate the effects of body mass index (BMI) on these associations.
A total of 5,674 women were enrolled from Jidong and Kailuan communities (Tangshan, Hebei) in Northern China. All participants completed standardized questionnaires, physical examination, and biochemical measurements. Logistic regression analysis was used to test the associations.
Compared with women with parity of one, nulliparous women had decreased odds ratios ( s ); those with parity of two had odds of abdominal obesity [ = 1.45, 95% confidence interval ( ) 1.17-1.81, < 0.001], high blood pressure ( = 1.26, 95% 1.03-1.54, = 0.025), elevated fasting glucose levels ( = 1.36, 95% 1.03-1.79, = 0.029), and MetS ( = 1.39, 95% 1.13-1.73, = 0.002); and those with parity of three or more had increased odds of elevated triglyceride levels ( = 1.42, 95% 1.04-1.94, = 0.027) and MetS ( = 1.50, 95% 1.10-2.05, = 0.011) after complete adjustment for confounders. Furthermore, BMI and age subgroups partially modified the associations between parity and MetS and its components.
Parity is positively associated with MetS and select components in women. BMI is an important modifier involved in the associations between parity and MetS.
本研究旨在评估生育次数与代谢综合征（MetS）及其各组分之间的相关性，并评估体重指数（BMI）对此类相关性的影响。
本研究共纳入了来自中国北部河北省冀东和开滦社区（唐山）的 5674 名女性。所有参与者均完成了标准化问卷、体格检查和生化测量。采用 logistic 回归分析来检验相关性。
与生育一次的女性相比，未生育的女性发生腹型肥胖的比值比（ORs）降低（s）；生育两次的女性发生高血压（OR = 1.26，95%CI 1.03-1.54，p = 0.025）、空腹血糖水平升高（OR = 1.36，95%CI 1.03-1.79，p = 0.029）、代谢综合征（OR = 1.39，95%CI 1.13-1.73，p = 0.002）的风险更高；生育三次或以上的女性发生高甘油三酯血症（OR = 1.42，95%CI 1.04-1.94，p = 0.027）和代谢综合征（OR = 1.50，95%CI 1.10-2.05，p = 0.011）的风险更高。在完全调整混杂因素后，生育次数与代谢综合征及其各组分之间的相关性仍具有统计学意义。此外，BMI 和年龄亚组部分改变了生育次数与代谢综合征及其各组分之间的相关性。
生育次数与女性代谢综合征及其各组分呈正相关。BMI 是生育次数与代谢综合征相关性的一个重要调节因素。
