Department of Public Health Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan; Japan Society for the Promotion of Science, Japan; Center for Environmental and Health Sciences, Hokkaido University, Japan.
Department of Public Health Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Environ Int. 2020 Mar;136:105355. doi: 10.1016/j.envint.2019.105355. Epub 2020 Feb 4.
Prenatal maternal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) has been reportedly associated with decreased birth weight. Although a majority of epidemiological studies concerning perfluoroalkyl substances (PFAS) have focused on PFOS and PFOA, epidemiological studies of PFAS with longer carbon chains are scarce. In this study, we investigated whether prenatal maternal exposure to 11 PFAS, in particular those with longer carbon chains, is associated with fetal growth.
The study included 1985 mother-infant pairs (inclusive of preterm and post-term infants), who enrolled in a large-scale, prospective birth cohort study in any of the 37 hospitals in Hokkaido, Japan between 2003 and 2009. The concentration of 11 PFAS was measured in maternal plasma collected during the third trimester of pregnancy, using ultra-performance liquid chromatography in combination with triple quadrupole mass spectrometry. Associations between the measured PFAS values and weight, length, and head circumference of all newborns at birth were examined using multiple regression analyses with adjustment for potential confounders based on data collected from medical records, questionnaires, and those for maternal plasma samples.
Of the 11 PFAS analyzed, prenatal perfluorononanoic acid (PFNA) [per log10-unit: regression coefficient (β) = -96.2 g, 95% confidence intervals (95% CI), -165.3 to -27.1] and perfluorodecanoic acid (PFDA) (β = -72.2 g, 95% CI, -138.1 to -6.3) concentrations were inversely associated with birth weight. Furthermore, PFNA concentrations were inversely associated with birth length (per Log unit: β = -0.48 cm, 95% CI; - 0.86 to -0.11). Maternal perfluorotridecanoic acid (PFTrDA) exposure showed a significant inverse association with birth weight only for female infants (per Log unit: β = -99.8 g, 95% CI, - 193.7 to -6.0) (P for interaction = 0.04).
Our findings suggest that prenatal, maternal exposure to PFAS with longer carbon chains tends to be inversely associated with birth size of newborn infants, which may indicate that these commercially used compounds have an adverse effect on fetal growth.
已有报道称，母体在产前接触全氟辛烷磺酸（PFOS）和全氟辛酸（PFOA）会导致出生体重降低。尽管大多数有关全氟烷基物质（PFAS）的流行病学研究都集中在 PFOS 和 PFOA 上，但有关长链 PFAS 的流行病学研究却很少。在这项研究中，我们调查了母体在产前接触 11 种 PFAS，特别是那些长链的 PFAS，是否与胎儿生长有关。
该研究纳入了 1985 对母婴（包括早产儿和过期产儿），他们于 2003 年至 2009 年期间在日本北海道的 37 家医院中的任何一家参加了一项大规模的前瞻性出生队列研究。在妊娠晚期采集母体血浆样本，使用超高效液相色谱-三重四极杆质谱联用的方法来测量 11 种 PFAS 的浓度。使用多元回归分析，根据从病历、问卷调查和母体血浆样本中收集的数据，对所有新生儿出生时的体重、身长和头围与测量的 PFAS 值之间的关系进行了调整，以控制潜在的混杂因素。
在所分析的 11 种 PFAS 中，产前全氟壬酸（PFNA）[每 log10 单位：回归系数（β）= -96.2 g，95%置信区间（95%CI），-165.3 至 -27.1]和全氟癸酸（PFDA）（β= -72.2 g，95%CI，-138.1 至 -6.3）浓度与出生体重呈负相关。此外，PFNA 浓度与出生身长呈负相关（每 log 单位：β= -0.48 cm，95%CI；-0.86 至 -0.11）。母体全氟十三烷酸（PFTrDA）暴露仅与女性婴儿的出生体重呈显著负相关（每 log 单位：β= -99.8 g，95%CI，-193.7 至 -6.0）（P 交互= 0.04）。
我们的研究结果表明，母体在产前接触长链碳的 PFAS 与新生儿出生体重呈负相关，这可能表明这些商业上使用的化合物对胎儿生长有不利影响。
