Alconchel F, Martínez-Alarcón L, Nicolás-López T, Khiri F, Febrero B, Cascales-Campos P A, Martínez-Insfran L A, Ríos A, Fernández-Hernández J A, Rodríguez J M, López-López V, Sánchez-Bueno F, Robles-Campos R, Parrilla P, Ramírez P
Department of Surgery, Virgen de la Arrixaca University Hospital, Murcia, Spain; Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), Murcia, Spain.
Department of Surgery, Virgen de la Arrixaca University Hospital, Murcia, Spain; Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), Murcia, Spain.
Transplant Proc. 2020 Mar;52(2):549-552. doi: 10.1016/j.transproceed.2019.12.032. Epub 2020 Feb 4.
Sarcopenia is defined as the loss of muscle mass and function. Our aim is to evaluate the degree of sarcopenia by measuring the patients on the waiting list for liver transplantation and its influence on the different post-liver transplant outcomes in our group.
The psoas muscle index (PMI, cm/m) was calculated (right psoas muscle area [cm]/the square of the body height [m]) in 57 patients on the waiting list for liver transplantation in our center, and the post-transplant variables relevant to our study were collected.
The 57 recipients had a mean age of 57 years (range, 35-73) and had a mean of 7.4 months (range, 0-39) on the liver transplant waiting list. The mean psoas muscle index was 2.39 (range, 1-4), and the mean body mass index was 28.01kg/m (range, 22-36). After multivariate analysis we found a positive correlation between the PMI and the body mass index of the recipients (r = 0.320, P = .017), intensive care unit length of stay, and donor age (r = 0.319, P = .042), and between cold ischemia time and graft survival (r = 0.366, P = .009). We found no correlation in our sample between PMI and post-liver transplant complications either in terms of graft or patient survival.
PMI is not representative of total muscle mass and sarcopenia and is not effective in adequately predicting the survival of patients on the waiting list for liver transplantation.
肌肉减少症被定义为肌肉质量和功能的丧失。我们的目的是通过测量肝移植等待名单上的患者来评估肌肉减少症的程度及其对我们组不同肝移植后结局的影响。
计算了我们中心57例肝移植等待名单上患者的腰大肌指数（PMI，cm/m）（右侧腰大肌面积[cm]/身高[m]的平方），并收集了与我们研究相关的移植后变量。
57例受者的平均年龄为57岁（范围35 - 73岁），在肝移植等待名单上的平均时间为7.4个月（范围0 - 39个月）。平均腰大肌指数为2.39（范围1 - 4），平均体重指数为28.01kg/m（范围22 - 36）。多因素分析后，我们发现受者的PMI与体重指数（r = 0.320，P = .017）、重症监护病房住院时间以及供体年龄（r = 0.319，P = .042）之间存在正相关，冷缺血时间与移植物存活之间存在正相关（r = 0.366，P = .009）。在我们的样本中，无论是移植物还是患者存活方面，PMI与肝移植后并发症之间均无相关性。
PMI不能代表总体肌肉质量和肌肉减少症，也不能有效预测肝移植等待名单上患者的存活情况。
