Molgó Montserrat, Espinoza-Benavides Leonardo, Rojas Patricio, González Sergio
Department of Dermatology, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile.
Department of Hematology, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile.
Indian J Dermatol. 2020 Jan-Feb;65(1):57-60. doi: 10.4103/ijd.IJD_16_19.
A 59-year-old man with Hodgkin's lymphoma was referred by a hematologist for consultation for cutaneous issues. Physical examination revealed generalized scaling and erythematous scaly patches located in the groin, abdomen, and arms. The biopsy was compatible with mycosis fungoides (MF). At his next medical visit, painful nodules with erythematous halo and scabby surface were noted, and a subsequent biopsy was compatible with lymphomatoid papulosis (LyP). Mycosis fungoides, the most common primary cutaneous T-cell lymphoma, is usually defined in its classic form as a CD4 non-Hodgkin lymphoma; LyP corresponds to a CD30 lymphoproliferative disorder; and Hodgkin's lymphoma (HL) constitutes a lymphoid neoplasia characterized by the presence of Reed-Sternberg cells and its variants. Although these entities have been defined independently, evidence suggests the possibility of a common monoclonal origin. To our knowledge, this is the first case of MF, LyP, and HL in a single patient.
一名59岁的霍奇金淋巴瘤患者由血液科医生转诊，就皮肤问题进行会诊。体格检查发现腹股沟、腹部和手臂有全身性鳞屑及红斑鳞屑性斑块。活检结果符合蕈样肉芽肿（MF）。在他的下一次就诊时，发现了伴有红斑晕和结痂表面的疼痛性结节，随后的活检结果符合淋巴瘤样丘疹病（LyP）。蕈样肉芽肿是最常见的原发性皮肤T细胞淋巴瘤，其经典形式通常被定义为CD4非霍奇金淋巴瘤；LyP对应于CD30淋巴增殖性疾病；霍奇金淋巴瘤（HL）是一种以里德-斯腾伯格细胞及其变体为特征的淋巴样肿瘤。尽管这些实体已被独立定义，但有证据表明它们可能有共同的单克隆起源。据我们所知，这是首例单一患者同时患有MF、LyP和HL的病例。
