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胸膜切除术及楔形切除术与单纯胸膜切除术治疗原发性自发性气胸患者的疗效及安全性比较

Efficacy and safety of pleurectomy and wedge resection versus simple pleurectomy in patients with primary spontaneous pneumothorax.

作者信息

Dżeljilji Agata, Karuś Krzysztof, Kierach Artur, Kazanecka Barbara, Rokicki Wojciech, Tomkowski Witold

机构信息

Department of Thoracic Surgery, National Institute of Tuberculosis and Lung Diseases (NITLD), Warsaw, Poland.

Kierach Clinic, Tychy, Poland.

出版信息

J Thorac Dis. 2019 Dec;11(12):5502-5508. doi: 10.21037/jtd.2019.11.28.

Abstract

BACKGROUND

The treatment of primary spontaneous pneumothorax (PSP) remains controversial. Guidelines do not explicitly define surgical procedures. Different treatment modalities are observed in clinics of same profile. Treatment is controversial. The aim of the work was to compare the effectiveness of two methods-pleurectomy and pleurectomy combined with wedge resection in patients with PSP in terms of safety and efficiency.

METHODS

Non-randomized observational study based on clinical analysis of 73 patients, M:F ratio 3:1, aged 18 to 45 years, the average age was 29 years, operated between January 2008 and December 2014 due to the occurrence of PSP. Pleurectomy was supplemented by wedge resection in patients diagnosed intraoperatively with ELC (emphsema-like changes) ≥ III stage (classification of PSP by Vanderschueren). Efficacy was defined as follows: complete lung expansion, drainage (days), air leak, frequency of PAL (persistent air leak >5 days), recurrences and re-operations. Safety was defined as follows: heamothorax, major bleeding (loss of Hg >2 g/dL), infections, deaths. The research project was approved by the Bioethical Commission of the Silesian Medical University in Katowice (KNW/022/kb1/3/14).

RESULTS

Mean follow-up was 22 months. Efficacy: recurrences occurred less frequently in group treated with pleurectomy without wedge resection. No results were found in other parameters. Safety: No results were found in all parameters.

CONCLUSIONS

Efficacy and safety of pleurectomy pleurectomy + wedge resection is comparable.

摘要

背景

原发性自发性气胸(PSP)的治疗仍存在争议。指南未明确界定手术程序。在相同类型的临床诊所中观察到不同的治疗方式。治疗存在争议。本研究的目的是比较胸膜切除术和胸膜切除术联合楔形切除术这两种方法在PSP患者中的安全性和有效性。

方法

基于对73例患者的临床分析进行非随机观察性研究,男女比例为3:1,年龄在18至45岁之间,平均年龄为29岁,于2008年1月至2014年12月因PSP发作而接受手术。术中诊断为ELC(肺气肿样改变)≥III期(根据Vanderschueren的PSP分类)的患者,胸膜切除术辅以楔形切除术。疗效定义如下:肺完全复张、引流天数、气胸漏气、PAL(持续性气胸漏气>5天)频率、复发率和再次手术率。安全性定义如下:血胸、大出血(血红蛋白损失>2 g/dL)、感染、死亡。该研究项目获得了卡托维兹西里西亚医科大学生物伦理委员会的批准(KNW/022/kb1/3/14)。

结果

平均随访22个月。疗效:未行楔形切除术的胸膜切除术组复发率较低。其他参数未发现差异。安全性:所有参数均未发现差异。

结论

胸膜切除术与胸膜切除术+楔形切除术的疗效和安全性相当。

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本文引用的文献

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Spontaneous pneumothorax: time to rethink management?自发性气胸:是否需要重新考虑治疗方法?
Lancet Respir Med. 2015 Jul;3(7):578-88. doi: 10.1016/S2213-2600(15)00220-9.

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