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肺毛霉病在急性髓系白血病期间发生,并在血液干细胞移植前通过手术切除成功治疗。

Pulmonary mucormycosis developed during acute myelogenous leukemia and successfully treated by surgical resection before blood stem cell transplantation.

作者信息

Miura Kentaro, Kobayashi Nobutaka, Ito Ichiro, Uematsu Nozomu, Ueki Toshimitsu, Nakano Yuta, Kobayashi Hikaru

机构信息

Division of Thoracic Surgery, Japanese Red Cross Society Nagano Hospital, Nagano, Japan.

Department of Pathology, Japanese Red Cross Society Nagano Hospital, Nagano, Japan.

出版信息

AME Case Rep. 2019 Dec 27;3:48. doi: 10.21037/acr.2019.11.02. eCollection 2019.

Abstract

Pulmonary mucormycosis is relatively rare and occurs in immunosuppressed patients, for example, individuals with hematologic malignancies such as leukemia. As pulmonary mucormycosis increases rapidly and is often fatal, appropriate treatment including surgical resection is necessary. We report a patient with pulmonary mucormycosis and acute myelogenous leukemia for which antifungal drugs were invalid. After rapid surgical resection, the patient was administered a peripheral blood stem cell transplantation. In conclusion, we emphasize that patients with pulmonary mucormycosis undergoing leukemia treatment should be considered for rapid surgical treatment if the infected lesion is limited, as overcoming this acute infection increases their chance to undergo hematopoietic stem cell transplantation and potential for long-term survival.

摘要

肺毛霉病相对罕见,发生于免疫抑制患者,例如患有白血病等血液系统恶性肿瘤的个体。由于肺毛霉病进展迅速且常致命,因此包括手术切除在内的适当治疗是必要的。我们报告了一例患有肺毛霉病和急性髓系白血病的患者,抗真菌药物对其无效。在快速手术切除后,该患者接受了外周血干细胞移植。总之,我们强调,对于正在接受白血病治疗的肺毛霉病患者,如果感染病灶局限,应考虑进行快速手术治疗,因为克服这种急性感染可增加他们接受造血干细胞移植的机会和长期生存的可能性。

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