Kang C M, Kim H S, Song K S, Lee H J, Kwon K Y
Department of Pediatrics, Keimyung University, School of Medicine, Taegu, Korea.
Jpn J Clin Oncol. 1997 Oct;27(5):357-60. doi: 10.1093/jjco/27.5.357.
Mucormycosis is a rare fungal infection of childhood, occurring mainly in patients with chronic illnesses such as diabetes and malignancies. The fungus seldom grows in culture and confirmation of the diagnosis depends on histologic examination of infected tissues. To date, the reported natural history of the disease has been rapid progression and a fatal outcome. Therefore, the importance of early diagnosis by tissue biopsy and early treatment with surgical debridement and systemic antifungal therapy cannot be overemphasized. The pulmonary system is the most common site for mucormycosis in patients with leukemia. We report what we believe to be the first successfully treated case of isolated muscular mucormycosis occurring in a child with biphenotypic acute leukemia. The diagnosis was made promptly by tissue examination at the time of surgical debridement. The patient was also given systemic amphotericin-B therapy.
毛霉菌病是一种罕见的儿童真菌感染，主要发生于患有糖尿病和恶性肿瘤等慢性疾病的患者。该真菌在培养中很少生长，诊断的确立依赖于对感染组织的组织学检查。迄今为止，所报道的该疾病自然病程为进展迅速且预后致命。因此，通过组织活检进行早期诊断以及采用手术清创和全身性抗真菌治疗进行早期治疗的重要性无论如何强调都不为过。肺部是白血病患者中毛霉菌病最常见的发病部位。我们报告了我们认为是首例成功治疗的孤立性肌肉毛霉菌病病例，该病例发生于一名双表型急性白血病患儿。在手术清创时通过组织检查迅速做出了诊断。该患者还接受了全身性两性霉素B治疗。
