基于 BODIPY 的荧光传感器用于检测 Pt2+ 和 Pt 药物。
A BODIPY-based fluorescent sensor for the detection of Pt2+ and Pt drugs.
机构信息
Department of Chemistry, State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, P. R. China.
Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, P. R. China.
出版信息
Chem Commun (Camb). 2020 Mar 3;56(18):2695-2698. doi: 10.1039/d0cc00027b.
A BODIPY-based fluorescent sensor PS with an NO4S2 podand ligand was studied for the selective detection of Pt2+ over 21 cations as well as selected platinum drugs in aqueous medium. The platinum sensor PS shows 28-fold, 22-fold and 14-fold fluorescence turn-on enhancements to Pt2+, cisplatin and nedaplatin, and was thereby employed to detect platinum drugs in A-549 human lung cancer cells.
研究了一种基于 BODIPY 的荧光传感器 PS，该传感器带有一个 NO4S2 穴状配体，可用于在水相中选择性检测 Pt2+，对 21 种阳离子以及一些铂类药物也有选择性。Pt2+、顺铂和奈达铂可使该铂类传感器 PS 的荧光强度分别增强 28 倍、22 倍和 14 倍，因此可用于检测 A-549 人肺癌细胞中的铂类药物。
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