College of Medicine, Catholic Hematology Hospital, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
Division of Medical Oncology, Department of Internal Medicine, College of Medicine, Eunpyeong St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
Br J Haematol. 2020 May;189(3):518-523. doi: 10.1111/bjh.16413. Epub 2020 Feb 6.
We explored prognostic roles of circulating microRNAs (miRs) in multiple myeloma (MM) treated with autologous stem cell transplantation (ASCT) following induction chemotherapy. In part I of the study (n = 40), we identified a decreasing dynamics of circulating miR-193a-5p expression from diagnosis to pre-ASCT. In patients who experienced early relapse within one year post ASCT (n = 9) these patterns were distinctive compared to those without early relapse in a 1:2 matched cohort (n = 18). In part II (n = 90), multivariate analyses showed that the International Staging System score and miR-193a-5p expression before ASCT were independent prognostic factors. Conclusively, expression of circulating miR-193a-5p before ASCT could be a prognostic biomarker for transplant-eligible MM.
我们探讨了自体造血干细胞移植（ASCT）治疗多发性骨髓瘤（MM）后循环微小 RNA（miRs）的预后作用，此前采用诱导化疗。在研究的第一部分（n=40）中，我们从诊断到 ASCT 前发现了循环 miR-193a-5p 表达的下降动态。与未在 ASCT 后一年内早期复发的患者（n=18）相比，在 1:2 匹配队列中（n=9），这些模式在早期复发的患者中具有独特性。在第二部分（n=90）中，多变量分析显示，ASCT 前国际分期系统评分和 miR-193a-5p 表达是独立的预后因素。总之，ASCT 前循环 miR-193a-5p 的表达可能是适合移植的 MM 的预后生物标志物。
