作为氧化应激标志物的脯氨酰肽酶活性与阻塞性睡眠呼吸暂停综合征严重程度之间是否存在关联？

Is there a correlation between obstructive sleep-apnea syndrome severity and prolidase activity as an oxidative stress marker?

作者信息

Gunbatar H, Kaplan H S, Yildiz S

机构信息

Department of Pulmonary and Critical Care, Yuzuncu Yil University Medical Faculty, Kampüsü, 65090 Tusba/Van, Turkey.

Anaesthesia and Reanimations, Yuzuncu Yil University Medical Faculty, Kampüsü, 65090 Tusba/Van, Turkey.

出版信息

Niger J Clin Pract. 2020 Feb;23(2):252-257. doi: 10.4103/njcp.njcp_381_18.

DOI:10.4103/njcp.njcp_381_18

PMID:32031102

Abstract

OBJECTIVE

Obstructive sleep apnea syndrome (OSAS) is a highly prevalent breathing disorder in sleep. The aim of this study was to evaluate the relationship between OSAS and prolidase activity, the oxidative stress index (OSI), total antioxidative capacity (TAC), total oxidative capacity (TOC) and the carotid intima media thickness (CIMT).

METHOD

: After night polysomnography, 74 people were diagnosed with OSAS and simple snoring. Plasma prolidase activities, TAC and TOC were measured in blood samples taken in the morning after the sleep study. The patients' bilateral common carotid arteries were scanned.

RESULTS

In total, 56 patients were in OSAS group [13 subjects 23.2% mild, 19 subjects 33.9% moderate, 24 subjects 42.8% severe] and 18 in simple snoring control group. The mean Prolidase, TOC, TAC and OSI levels were 744.7 ± 156.8, 59.2 ± 19.2, 2.12 ± 0.41, 3.12 ± 1.03, in the mild OSAS group, 761.6 ± 114.4, 57.9 ± 18.3, 2.03 ± 0.37, 3.15 ± 0.8, in the moderate OSAS group, 754.08 ± 133.9, 51.15 ± 12.1, 1.97 ± 0.27, 2.8 ± 0.82, in the severe OSAS group, and 711.9 ± 139, 52.3 ± 15.1, 1.83 ± 0.32, 3.06 ± 0.92 in the control group, respectively. Mean CIMT measurements were 0.71(±0,13) in the OSAS group and 0.76(±0.07) in the control group.

CONCLUSION

There was no difference between the control and OSAS groups in terms of the parameters studied. Further studies should be undertaken in order to clarify the relation.

摘要

目的

阻塞性睡眠呼吸暂停综合征（OSAS）是一种睡眠中高度常见的呼吸障碍。本研究的目的是评估OSAS与脯氨肽酶活性、氧化应激指数（OSI）、总抗氧化能力（TAC）、总氧化能力（TOC）以及颈动脉内膜中层厚度（CIMT）之间的关系。

方法

在进行夜间多导睡眠图检查后，74人被诊断为患有OSAS和单纯打鼾。在睡眠研究后的早晨采集血样，测量血浆脯氨肽酶活性、TAC和TOC。对患者的双侧颈总动脉进行扫描。

结果

总共56例患者在OSAS组[13例受试者23.2%为轻度，19例受试者33.9%为中度，24例受试者42.8%为重度]，18例在单纯打鼾对照组。轻度OSAS组中脯氨肽酶、TOC、TAC和OSI的平均水平分别为744.7±156.8、59.2±19.2、2.12±0.41、3.12±1.03；中度OSAS组中分别为761.6±114.4、57.9±18.3、2.03±0.37、3.15±0.8；重度OSAS组中分别为754.08±133.9、51.15±12.1、1.97±0.27、2.8±0.82；对照组中分别为711.9±139、52.3±15.1、1.83±0.32、3.06±0.92。OSAS组的平均CIMT测量值为0.71（±0.13），对照组为0.76（±0.07）。